Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and regulation are reduced. Authors also note an overlap of genes associated with SARS-CoV-2 infection and tuberculosis, altogether providing new insights into the immunopathogenesis of COVID-19 disease.
- Bruce A. Rosa
- Mushtaq Ahmed
- Shabaana A. Khader
