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Showing 1–5 of 5 results
Advanced filters: Author: Joseph R Podojil Clear advanced filters

  • Oligodendrocyte death in the DTA mouse model leads to a fatal, secondary demyelinating disease associated with CNS T cell infiltration and myelin antigen-specific T cells in lymphoid organs, which can transfer a mild neurological disease to naive mice, indicating that oligodendrocyte death is sufficient to trigger an adaptive autoimmune response against myelin. These results suggest that the disease-initiating event in the autoimmune disorder multiple sclerosis may occur within the CNS.

    • Maria Traka
    • Joseph R Podojil
    • Brian Popko
    Research
    Nature Neuroscience
    Volume: 19, P: 65-74

  • Current multiple sclerosis treatments focus on prevention of immune attack on oligodendrocytes and myelin. Here the authors show a different strategy to ameliorate disease in several mouse models, protecting oligodendrocytes from inflammation-induced death with an FDA-approved drug, guanabenz.

    • Sharon W. Way
    • Joseph R. Podojil
    • Brian Popko
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Therapeutic strategies that induce antigen-specific immune tolerance without suppressing the ability of the immune system to respond to infectious agents are needed for the treatment of autoimmune diseases. But how might these antigen-specific therapies induce tolerance and are they safe for use in the clinic?

    • Stephen D. Miller
    • Danielle M. Turley
    • Joseph R. Podojil
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 665-677