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Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

Sepsis is a global challenge and a significant burden in Sub-Saharan Africa. Here, Chenoweth et al profile host gene expression signatures from a cohort in Ghana to define molecular phenotypes and identify potential targets to improve patient outcomes.

Josh G. Chenoweth
Carlo Colantuoni
Danielle V. Clark
ResearchOpen Access30 May 2024
Nature Communications

Volume: 15, P: 1-13
New cell lines from mouse epiblast share defining features with human embryonic stem cells

Mouse and human embryonic stem (ES) cells use different signalling pathways to maintain their pluripotent status. Now, a new kind of pluripotent ES cell is described. This cell type is derived from mouse embryos after they implant in the wall of the uterus, and shares many defining features with human ES cells, including signalling responses that control differentiation to somatic fates.

Paul J. Tesar
Josh G. Chenoweth
Ronald D. G. McKay
Research27 Jun 2007
Nature

Volume: 448, P: 196-199
Sepsis endotypes identified by host gene expression across global cohorts

Chenoweth et al. investigate heterogeneity in sepsis using host gene expression from multi-site international cohorts. Endotypes differentiated by mortality are identified and related molecular signatures implicate immune dysfunction in sepsis pathophysiology.

Josh G. Chenoweth
Joost Brandsma
Danielle V. Clark
ResearchOpen Access18 Jun 2024
Communications Medicine

Volume: 4, P: 1-9
7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages

Giuseppe Testa and colleagues report the generation and transcriptional characterization of patient-derived induced pluripotent stem cells (iPSCs) with copy number variants at 7q11.23, which cause syndromes including neurocognitive phenotypes. They find that the dosage of the transcription factor gene GTF2I accounts for 10–20% of the transcriptional dysregulation observed in these cells.

Antonio Adamo
Sina Atashpaz
Giuseppe Testa
Research15 Dec 2014
Nature Genetics

Volume: 47, P: 132-141
Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19

Paul W. Blair
Joost Brandsma
N. Huprikar
ResearchOpen Access28 Dec 2022
Scientific Reports

Volume: 12, P: 1-10

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Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes

New cell lines from mouse epiblast share defining features with human embryonic stem cells

Sepsis endotypes identified by host gene expression across global cohorts

7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages

Distinct blood inflammatory biomarker clusters stratify host phenotypes during the middle phase of COVID-19

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