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Showing 1–12 of 12 results
Advanced filters: Author: Joshua D Berke Clear advanced filters

  • Mohebi et al. report that dopamine (DA) pulses in different rat striatal subregions signal prediction errors across different timescales. In this way, one learning process may achieve a range of adaptive behaviors.

    • Ali Mohebi
    • Wei Wei
    • Joshua D. Berke
    ResearchOpen Access
    Nature Neuroscience
    Volume: 27, P: 737-746

  • The dopamine projection from midbrain dopamine cells to the nucleus accumbens is essential for normal motivation, yet motivation-related changes in nucleus accumbens dopamine release occur independently of dopamine cell firing.

    • Ali Mohebi
    • Jeffrey R. Pettibone
    • Joshua D. Berke
    Research
    Nature
    Volume: 570, P: 65-70

  • Red and yellow versions of the genetically encoded dopamine sensor dLight1 have been developed and allow multiplexed imaging of dopamine with neurotransmitter or cell-type-specific calcium combined with green sensors or actuators, as demonstrated ex vivo and in behaving rodents.

    • Tommaso Patriarchi
    • Ali Mohebi
    • Lin Tian
    Research
    Nature Methods
    Volume: 17, P: 1147-1155

  • In this Perspective, Josh Berke discusses recent developments in the study of dopamine function. He proposes a model that explains how dopamine can serve as both a learning signal and as a critical modulator of motivated decision-making.

    • Joshua D. Berke
    Reviews
    Nature Neuroscience
    Volume: 21, P: 787-793

  • Seeking insight into dopamine's contribution to motivation and learning, the authors examined dopamine release in the rat nucleus accumbens during adaptive decision-making. Dopamine levels convey a running estimate of available future reward, which is used to decide whether it's worthwhile to engage in a behavioral task. Abrupt fluctuations serve as reward prediction errors, reinforcing behavioral choices.

    • Arif A Hamid
    • Jeffrey R Pettibone
    • Joshua D Berke
    Research
    Nature Neuroscience
    Volume: 19, P: 117-126

  • Distinct dopaminergic neurons in the ventral tegmental area respond to physiological fluid balance and nutrient cues at specific stages of ingestion, driving learning about the physiological effects of ingestion.

    • James C. R. Grove
    • Lindsay A. Gray
    • Zachary A. Knight
    ResearchOpen Access
    Nature
    Volume: 608, P: 374-380

  • Rapid action suppression is often modeled as a race between 'Go' and 'Stop' processes, but how this corresponds to brain mechanisms has been unclear. The authors recorded simultaneously from multiple rat basal ganglia structures during a Stop-signal task and found Go-related activity in striatum and stop-related activity in the subthalamic nucleus. These distinct signals provide convergent, competing influences over individual cells in the substanti anigra pars reticulata, whose activity reflects whether stopping is successful or not. The results tie together neurophysiology and psychological theory to provide a mechanistic account of how we can or cannot cancel forthcoming actions.

    • Robert Schmidt
    • Daniel K Leventhal
    • Joshua D Berke
    Research
    Nature Neuroscience
    Volume: 16, P: 1118-1124