Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–11 of 11 results
Advanced filters: Author: Joshua D. Ooi Clear advanced filters
  • Antigen specific regulatory T cells (Treg) play key roles in the peripheral tolerance to suppress autoreactive immune cells and represent potential avenue for therapeutic intervention. Here the authors identify Smith specific Treg and engineer Treg based cell therapy showing suppression of inflammation in a murine model of lupus nephritis.

    • Peter J. Eggenhuizen
    • Rachel M. Y. Cheong
    • Joshua D. Ooi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14
  • Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas.

    • Don A. Driscoll
    • Kristina J. Macdonald
    • Ryan D. Phillips
    ResearchOpen Access
    Nature
    Volume: 635, P: 898-905
  • Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO autoimmunity and glomerulonephritis in mice.

    • Joshua D. Ooi
    • Jhih-Hang Jiang
    • A. Richard Kitching
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14
  • The actin methyltransferase SETD3, by virtue of its ability to interact with the viral 2A protein and independently of its enzymatic activity, is necessary for RNA replication of several enteroviruses in cell culture and in vivo.

    • Jonathan Diep
    • Yaw Shin Ooi
    • Jan E. Carette
    Research
    Nature Microbiology
    Volume: 4, P: 2523-2537
  • A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

    • Caleb D. Marceau
    • Andreas S. Puschnik
    • Jan E. Carette
    Research
    Nature
    Volume: 535, P: 159-163
  • The glomerulus, unlike many capillary beds, readily supports leukocyte recruitment, but little is known about the actions of leukocytes upon recruitment to glomeruli. Devi and colleagues have addressed this issue with a multiphoton, confocal microscopy–based approach to shed light on glomerular inflammation. Induction of inflammation in mice did not increase the number of leukocytes recruited to glomeruli but prolonged the duration of leukocyte retention and migration.

    • Sapna Devi
    • Anqi Li
    • Michael J Hickey
    Research
    Nature Medicine
    Volume: 19, P: 107-112
  • This Review explores the mechanistic links underlying the associations between HLA and kidney diseases. The authors discuss how these links might provide insights into disease pathogenesis and describe the clinical implications of these insights.

    • Kate J. Robson
    • Joshua D. Ooi
    • A. Richard Kitching
    Reviews
    Nature Reviews Nephrology
    Volume: 14, P: 636-655