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Showing 1–4 of 4 results
Advanced filters: Author: Joshua D. Stender Clear advanced filters

  • Here the authors perform a gene knockout screen in myeloid cells, identifying 295 genes regulating interleukin-1β production, of which 57 lie in regions associated with inflammatory disease risk. The study sheds light on genetic control of interleukin-1β in inflammation, beyond previously known factors.

    • Fedik Rahimov
    • Sujana Ghosh
    • Joshua D. Stender
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.

    • Sonia Shah
    • Albert Henry
    • R. Thomas Lumbers
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.

    • Gregory J. Fonseca
    • Jenhan Tao
    • Christopher K. Glass
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.

    • Kavita Praveen
    • Gaurang C. Patel
    • Giovanni Coppola
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-15