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Showing 1–10 of 10 results
Advanced filters: Author: Joshua G. Schraiber Clear advanced filters

  • Studying the asymmetry in the pattern of Neanderthal introgression in modern human genomes between individuals of East Asian and European ancestry, the authors show recurrent gene flow from Neanderthals into modern humans.

    • Fernando A. Villanea
    • Joshua G. Schraiber
    Research
    Nature Ecology & Evolution
    Volume: 3, P: 39-44

  • Many rare high-impact variants have been associated with disease, but the origins and functional impact are not always explored. Here, the authors trace the ancestry of a rare high impact atrial fibrillation allele in KCNQ1, and use iPSC-derived cardiomyocytes to characterize the effect of the allele.

    • Shannon Hateley
    • Angelica Lopez-Izquierdo
    • Martin Tristani-Firouzi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Whole-genome alignment of 239 primate species reveals noncoding regulatory elements that are under selective constraint in primates but not in other placental mammals, that are enriched for variants that affect human gene expression and complex traits in diseases.

    • Lukas F. K. Kuderna
    • Jacob C. Ulirsch
    • Kyle Kai-How Farh
    ResearchOpen Access
    Nature
    Volume: 625, P: 735-742

  • This study presents the assembly and analysis of the genome sequence of a female domestic Duroc pig and a comparison with the genomes of wild and domestic pigs from Europe and Asia; the results shed light on the evolutionary relationship between European and Asian wild boars.

    • Martien A. M. Groenen
    • Alan L. Archibald
    • Lawrence B. Schook
    ResearchOpen Access
    Nature
    Volume: 491, P: 393-398

  • The rapid accumulation and increasing quality of human DNA sequence-variation data brought about by advances in genome-scale sequencing present opportunities to investigate human evolution. The authors discuss the statistical methods and models that can be used to gain insight into the evolution of human populations from analyses of large-scale genomic data sets, as well as the challenges associated with these approaches.

    • Joshua G. Schraiber
    • Joshua M. Akey
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 727-740

  • Laurent Frantz and colleagues report an analysis of 103 whole genomes from European and Asian wild boars and domestic pigs. They find evidence in support of a complex domestication model with gene flow from wild populations counteracted by recurrent artificial selection for traits important for domestication.

    • Laurent A F Frantz
    • Joshua G Schraiber
    • Martien A M Groenen
    Research
    Nature Genetics
    Volume: 47, P: 1141-1148

  • A sequencing study comparing ancient and contemporary genomes reveals that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, ancient north Eurasians (related to Upper Palaeolithic Siberians) and early European farmers of mainly Near Eastern origin.

    • Iosif Lazaridis
    • Nick Patterson
    • Johannes Krause
    Research
    Nature
    Volume: 513, P: 409-413