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Showing 1–2 of 2 results
Advanced filters: Author: Joshua Salafsky Clear advanced filters

  • Indoleamine 2,3-dioxygenase 1 (IDO1) is crucial in cancer-related immunosuppression, yet its signaling function remains underexplored in immunotherapy development. Here, the authors use second harmonic generation analysis and molecular dynamics simulations to reveal that clinical IDO1 inhibitors differentially modulate its signaling, impacting distinct transcriptomes.

    • Alice Coletti
    • Elisa Bianconi
    • Antonio Macchiarulo
    ResearchOpen Access
    Communications Chemistry
    Volume: 8, P: 1-12

  • Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational changes in G and discuss implications for receptor-activated virus entry.

    • Joyce J. W. Wong
    • Tracy A. Young
    • Theodore S. Jardetzky
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11