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Advanced filters: Author: Jotin Gogoi Clear advanced filters
  • The editing domains of AlaRS (AlaRS-Ed) and ThrRS (ThrRS-Ed) are homologous, yet they differ in sensitivity to reactive oxygen species (ROS). Here, the authors reveal the mechanistic basis of how the universally conserved Zn2+ ion safeguards AlaRS-Ed’s activity from ROS, while its absence in ThrRS-Ed renders its hypersensitive.

    • Jotin Gogoi
    • Komal Ishwar Pawar
    • Rajan Sankaranarayanan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16