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Showing 1–6 of 6 results
Advanced filters: Author: Jovylyn Gatchalian Clear advanced filters

  • The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing both cooperative and individual interactions.

    • Jovylyn Gatchalian
    • Xiaodong Wang
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Mutations of the histone H3K36-specific methyltransferase ASH1L have been linked to several human diseases. Here, the authors report the mechanism by which three C-terminal domains in ASH1L regulate its enzymatic activity and interact with chromatin.

    • Kendra R. Vann
    • Rajal Sharma
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Binding of the Tudor domain of the PHD finger protein PHF1 to H3K36me3 inhibits Polycomb PRC2 complex methyltransferase activity. Here, Musselman et al.characterize this interaction in the context of the full nucleosome and show dual binding of the PHF1 Tudor domain to H3K36me3 and double-stranded DNA.

    • Catherine A. Musselman
    • Matthew D. Gibson
    • Tatiana G. Kutateladze
    Research
    Nature Communications
    Volume: 4, P: 1-9

  • Clinical management of pancreatic cancer remains challenging. Here, the authors suggest SMARCD3 as a potential epigenetic dependency establishing the metabolic landscape in aggressive pancreatic cancer cells and as a potential therapeutic target in pancreatic cancer.

    • L. Paige Ferguson
    • Jovylyn Gatchalian
    • Tannishtha Reya
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • A CRISPR-based screening platform was used to identify previously uncharacterized genes that regulate the regulatory T cell-specific master transcription factor Foxp3, indicating that this screening method may be broadly applicable for the discovery of other genes involved in autoimmunity and immune responses to cancer.

    • Jessica T. Cortez
    • Elena Montauti
    • Deyu Fang
    Research
    Nature
    Volume: 582, P: 416-420

  • The BAF complex is a multi-subunit chromatin remodeling complex that plays important roles in transcription regulation. Here the authors provide evidence that BRD9 and GLTSCR1/BICRA or its paralog GLTSCR1-like/BICRAL define a non-canonical BAF complex that regulates naive pluripotency in mouse embryonic stem cells.

    • Jovylyn Gatchalian
    • Shivani Malik
    • Diana C. Hargreaves
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16