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Showing 1–4 of 4 results
Advanced filters: Author: Joyce Koenen Clear advanced filters
  • Fibroblasts play critical roles in tissue homeostasis, but in pathologic states they can drive fibrosis, inflammation, and tissue destruction. Here, Faust et al. find that healthy human synovial fibroblasts under the influence of adjacent adipocytes have altered lipid metabolism driven by cortisol signaling. Both adipocytes and these characteristics are lost in inflammatory arthritis.

    • Heather J. Faust
    • Tan-Yun Cheng
    • Michael B. Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20
  • The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and ACKR3-mediated inhibition of astrocyte gap junctional communication.

    • Amos Fumagalli
    • Joyce Heuninck
    • Philippe Marin
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • Using a mouse model harboring a WHIM Syndrome-linked gain-of-function CXCR4 mutation and bone marrow samples from WHIM patients, the authors show that proper CXCR4 signaling termination is essential for bone tissue homeostasis.

    • Adrienne Anginot
    • Julie Nguyen
    • Karl Balabanian
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20
  • Endothelial cell (EC) dysfunction and inflammation contribute to plaque destabilization in atherosclerosis, increasing the risk of thrombotic events. Here, the authors show that epsin promotes EC inflammation via a mechanism involving IP3R1 degradation, and that deletion of epsin in the endothelium prevents EC dysfunctoin and atherosclerosis in mice.

    • Yunzhou Dong
    • Yang Lee
    • Hong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16