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Showing 1–7 of 7 results
Advanced filters: Author: Juan I. Garaycoechea Clear advanced filters
  • DNA repair deficiency can cause tissue-specific phenotypes in humans and mice. Here, the authors find that p53 drives different, but tissue-specific responses despite the same defect in DNA repair. p53 drives blood stem cell loss but restrains liver polyploidisation in the absence of Ercc1.

    • Ross J. Hill
    • Nazareno Bona
    • Gerry P. Crossan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Endogenous and alcohol-derived acetaldehyde causes a specific pattern of DNA damage in haemopoietic stem cells; the effects are mitigated by detoxification, specific DNA repair mechanisms and a p53 response.

    • Juan I. Garaycoechea
    • Gerry P. Crossan
    • Ketan J. Patel
    Research
    Nature
    Volume: 553, P: 171-177
  • The DNA damage response is essential to genomic stability. Here, the authors discuss DNA damage-induced nephrotoxicity and kidney cancer, and the essential role of DNA repair in kidney homeostasis, as well as its potential to contribute to kidney dysfunction, including the links between DNA damage, cell-cycle control and ciliopathies.

    • Juan I. Garaycoechea
    • Catherine Quinlan
    • Martijn S. Luijsterburg
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 229-243