Mechanical forces modulate tumor cell phenotype, which in turn shapes the tumor microenvironment and contributes to downstream processes such as invasion and metastasis. Here authors show in primary patient-derived breast cancer explant cultures that low compression changes the tumour cells to a less differentiated state, leading to secretion of immunosuppressive cytokines, which impacts the tumor resident immune cells.
- Aino Peura
- Rita Turpin
- Pauliina M. Munne
