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Showing 1–7 of 7 results
Advanced filters: Author: Julia Ablaeva Clear advanced filters

  • The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.

    • Csaba Kerepesi
    • Margarita V. Meer
    • Vadim N. Gladyshev
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Hyaluronic acid is believed to plays a critical role in cancer resistance and longevity of the naked mole rat. Here, Zhao and colleagues show that accumulation of high levels of hyaluronic acid has co-evolved repeatedly in mammalian clades with adaptation to subterranean habitats.

    • Yang Zhao
    • Zhizhong Zheng
    • Vera Gorbunova
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Naked mole rat (NMR) is an exceptionally long-lived rodent species that on the phenotypic level seems to evade aging. Here the authors show that NMRs age epigenetically, while epigenetic clocks detect that NMR queens age more slowly than nonbreeding females.

    • Steve Horvath
    • Amin Haghani
    • Vera Gorbunova
    ResearchOpen Access
    Nature Aging
    Volume: 2, P: 46-59

  • Blind mole rats are small rodents characterized by an exceptionally long lifespan and resistance to both spontaneous and induced tumorigenesis. Gorbunova and colleagues show that a transposon-triggered innate immune response confers cancer resistance to the blind mole rat.

    • Yang Zhao
    • Ena Oreskovic
    • Vera Gorbunova
    Research
    Nature Immunology
    Volume: 22, P: 1219-1230

  • Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through several pathways, extended lifespan and improved healthspan.

    • Zhihui Zhang
    • Xiao Tian
    • Vera Gorbunova
    Research
    Nature
    Volume: 621, P: 196-205

  • Naked mole rats are the longest-lived rodents and produce very-high-molecular-mass hyaluronan (vHMM-HA). Here the authors show that naked mole rat vHMM-HA is better at protecting mouse and human cells from cell cycle arrest and cell death, compared to the high-molecular-mass hyaluronan produced by these species.

    • Masaki Takasugi
    • Denis Firsanov
    • Vera Gorbunova
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Naked mole rats seem almost entirely protected from developing cancer, and this can now, at least in part, be explained by the production of a unique high-molecular-mass form of hyaluronan, a component of the extracellular matrix; together with an increased sensitivity of naked mole-rat cells to hyaluronan signalling, this form protects its cells from oncogenic transformation.

    • Xiao Tian
    • Jorge Azpurua
    • Andrei Seluanov
    Research
    Nature
    Volume: 499, P: 346-349