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Showing 1–6 of 6 results
Advanced filters: Author: Julia I. Ellyard Clear advanced filters

  • TANK-binding kinase-1 (TBK1) and its homologue IκB kinase-ε (IKKε) are critical in the induction of the interferon response and the response to infection by pathogens. Here the authors show that pharmacological targeting of TBK1 AND IKKε reduces the immunopathology seen in a murine model of SARS-COV-2 infection.

    • Tomalika R. Ullah
    • Matt D. Johansen
    • Michael P. Gantier
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • Neutrophils are critical in the immune response to infective agents and have multiple effector strategies including the production of extracellular traps termed NETs. Here the authors show a link between NET production and Th17 differentiation which mechanistically occurs downstream of TLR2 signalling.

    • Alicia S. Wilson
    • Katrina L. Randall
    • Anne Brüstle
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • LNK is a potent negative regulator of cytokine signaling implicated in blood cells proliferation. Here the authors present structures of the substrate recognition (SH2) domain of LNK in complex with phosphorylated motifs from JAK2 and EPOR; providing insight into its binding specificity and mode of action.

    • Rhiannon Morris
    • Yaoyuan Zhang
    • Jeffrey J. Babon
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.

    • Simon H. Jiang
    • Vicki Athanasopoulos
    • Carola G. Vinuesa
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12