Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–6 of 6 results
Advanced filters: Author: Julia M. Marchingo Clear advanced filters

  • m1A58 is a common tRNA modification that can influence protein translational efficiency. Here Liu et al. reveal that tRNA methylation controls in vivo T cell activation by enhancing translation of the key transcription factor Myc.

    • Julia M. Marchingo
    News & Views
    Nature Immunology
    Volume: 23, P: 1401-1402

  • Professional antigen presenting cells (APC) are the major activator of T cells that then hone to sites of inflammation. Using islet cell grafts, here the authors show that parenchymal cells can present antigen to activate CD8+T cells at inflammatory sites, coining this a ‘mezzanine response’ distinct from primary and secondary responses associated with professional APCs.

    • Robyn M. Sutherland
    • Sarah L. Londrigan
    • Andrew M. Lew
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL proliferation, metabolism and effector function downstream of IL-15.

    • Olivia J. James
    • Maud Vandereyken
    • Mahima Swamy
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Quantitative systems-level proteomics is cleverly used to reveal a dynamic program of protein turnover in naive and memory CD4+ T cells that, alongside a stockpile of metabolic protein machinery, poises the cells for activation.

    • Julia M. Marchingo
    • Doreen A. Cantrell
    News & Views
    Nature Immunology
    Volume: 21, P: 827-828