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Showing 1–2 of 2 results
Advanced filters: Author: Julia Maracke Clear advanced filters

  • The main protease, a key enzyme of SARS-CoV-2, can protect itself from oxidative damage. Here, Reinke, Schubert, and colleagues used XFEL radiation to image the enzyme, revealing the disulfide and NOS/SONOS bonds that form in response to oxygen.

    • Patrick Y. A. Reinke
    • Robin Schubert
    • Thomas J. Lane
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Boronate-based ß-lactamase inhibitors play an important role in treating multidrug-resistant bacteria infection, however, the molecular mechanism of inhibition remains unclear. Here, the authors use time-resolved serial crystallography to investigate the binding process by using boric acid as a model against β-lactamase CTX-M-14, revealing the binding to the active site serine within 80–100 ms, a subsequent 1,2-diol boric ester formation with glycerol within 100–150 ms, as well as the displacement of the sulfate anion in the active site.

    • Andreas Prester
    • Markus Perbandt
    • Christian Betzel
    ResearchOpen Access
    Communications Chemistry
    Volume: 7, P: 1-12