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Showing 1–3 of 3 results
Advanced filters: Author: Julia Ritterhoff Clear advanced filters

  • In this Review, Ritterhoff and Tian describe the metabolic reprogramming that occurs in cardiac hypertrophy and heart failure; discuss the contribution of metabolism to energy-generating and non-energy-generating functions, including signalling, protein function and gene expression regulation; and highlight the role of metabolism in non-cardiomyocytes and the potential to develop metabolic therapies for heart failure.

    • Julia Ritterhoff
    • Rong Tian
    Reviews
    Nature Reviews Cardiology
    Volume: 20, P: 812-829

  • Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling.

    • Dan Shao
    • Outi Villet
    • Rong Tian
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes.

    • Lorenz H Lehmann
    • Zegeye H Jebessa
    • Johannes Backs
    Research
    Nature Medicine
    Volume: 24, P: 62-72