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Showing 1–6 of 6 results
Advanced filters: Author: Julia Schaletzky Clear advanced filters

  • Despite approved vaccines and anti-virals to prevent and treat SARS-CoV-2 infection, there is a need for further development of efficient antiviral therapeutic strategy. Here, Zhu et al. develop locked nucleic acid antisense oligonucleotides (LNA ASOs) targeting the 5’ leader sequence of SARS-CoV-2 RNA to interfere with replication of wildtype virus and variants of concern. Daily intranasal administration in K18-hACE2 humanized mice suppresses viral infection in lung.

    • Chi Zhu
    • Justin Y. Lee
    • Anders M. Näär
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Neuromuscular disease is often marked by insufficient neural activation of muscle activity, resulting in muscle weakness. Fady Malik and colleagues have developed an orally available small molecule that sensitizes muscles to neural activity by reducing the off rate of calcium binding to troponin C. They validate the therapeutic potential of this drug in vivo in a rat model of myasthenia gravis and show that treatment improves grip strength by 50%.

    • Alan J Russell
    • James J Hartman
    • Fady I Malik
    Research
    Nature Medicine
    Volume: 18, P: 452-455