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Mucosal Immunology (1)
Communications Biology (1)

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Advanced filters: Author: Julia Schanin Clear advanced filters

Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.

Julia Schanin
Wouter Korver
Bradford A. Youngblood
ResearchOpen Access11 Nov 2022
Communications Biology

Volume: 5, P: 1-13
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation

Julia Schanin
Simon Gebremeskel
Bradford A. Youngblood
ResearchOpen Access19 Aug 2020
Mucosal Immunology

Volume: 14, P: 366-376

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Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation

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