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Showing 1–3 of 3 results

Advanced filters: Author: Julian Naderi Clear advanced filters

An activity-specificity trade-off encoded in human transcription factors

Naderi et al. show that increasing the dispersion of aromatic residues in intrinsically disordered regions of human transcription factors enhances their activity but reduces their specificity.

Julian Naderi
Alexandre P. Magalhaes
Denes Hnisz
ResearchOpen Access05 Jul 2024
Nature Cell Biology

Volume: 26, P: 1309-1321
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

The role of circular RNAs (circRNAs) in modulating gene expression in cancer remains to be investigated. Here, the authors perform whole transcriptome sequencing in 104 primary neuroblastomas and reveal the involvement of MYCN in regulating circRNAs.

Steffen Fuchs
Clara Danßmann
Johannes H. Schulte
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-21
Hijacking of transcriptional condensates by endogenous retroviruses

TRIM28 depletion in embryonic stem cells disconnects transcriptional condensates from super-enhancers, which is rescued by knockdown of endogenous retroviruses.

Vahid Asimi
Abhishek Sampath Kumar
Denes Hnisz
ResearchOpen Access21 Jul 2022
Nature Genetics

Volume: 54, P: 1238-1247