Sensory processing deficits are observed in individuals with Rett syndrome and MeCP2-deficient mice. Here, the authors show that it is the loss of MeCP2 specifically in forebrain inhibitory neurons that leads to deficits in auditory-evoked local field potentials and elicits the seizures observed in MeCP2-deficient mice.
- Darren Goffin
- Edward S Brodkin
- Zhaolan Zhou