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Showing 1–8 of 8 results
Advanced filters: Author: Julie Brind’Amour Clear advanced filters
  • Standard ChIP-seq protocols require large numbers of cells for high-quality datasets, limiting the application of this technique on rare cell types. Here, Brind’Amour et al. introduce an ultra-low-input ChIP-seq protocol to generate maps of covalent histone marks from as few as 1,000 cells.

    • Julie Brind’Amour
    • Sheng Liu
    • Matthew C. Lorincz
    Research
    Nature Communications
    Volume: 6, P: 1-8
  • Although many species-specific imprinted genes have been identified, how the evolutionary switch from biallelic to imprinted expression occurs is still unknown. Here authors find that lineage-specific ERVs active as oocyte promoters can induce de novo DNA methylation at gDMRs and imprinting.

    • Aaron B. Bogutz
    • Julie Brind’Amour
    • Louis Lefebvre
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14
  • The combination of in situ hybridization of fluorescent probes onto chromosomes in solution and flow cytometry allows the quantitative identification of repeat sequences in individual chromosomes.

    • Julie Brind'Amour
    • Peter M Lansdorp
    Research
    Nature Methods
    Volume: 8, P: 484-486
  • The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which induces transcriptional silencing of this allele in the early embryo.

    • Julien Richard Albert
    • Wan Kin Au Yeung
    • Matthew Lorincz
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Histone acetylation is a ubiquitous hallmark of transcription. Here the authors provide evidence that the majority of histone acetylation is dependent on transcription, specifically due to the requirement of RNAPII for the recruitment and activity of histone acetyltransferases.

    • Benjamin J. E. Martin
    • Julie Brind’Amour
    • LeAnn J. Howe
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9
  • De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.

    • Julie Brind’Amour
    • Hisato Kobayashi
    • Matthew C. Lorincz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14
  • Post-translational histone modifications are important regulators of nuclear reprogramming. A study now reveals that histone lysine demethylase KDM4A-mediated H3K9me3 demethylation in mammalian oocytes is essential for zygotic genome activation and preimplantation development.

    • Julie Brind’Amour
    • Matthew C. Lorincz
    News & Views
    Nature Cell Biology
    Volume: 22, P: 355-357