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Advanced filters: Author: Julie Soutourina Clear advanced filters

  • Transcription is tightly regulated and universal across all domains of life. A study proposes how, during eukaryotic evolution, the emergence of a regulatory mechanism consisting of a focused promoter-proximal pause of RNA polymerase II could have originated from a proto-pause with the acquisition of negative elongation factor (NELF) subunits.

    • Julie Soutourina
    News & Views
    Nature Structural & Molecular Biology
    Volume: 33, P: 195-197

  • The evolutionarily conserved mediator of RNA polymerase II transcription (Mediator) complex is a general regulator of transcription. Recent structural and functional studies have provided important insights into the mechanisms of transcription activation by Mediator and have also revealed a new function of this complex in genome organization and suggested that it could be therapeutically targeted in disease.

    • Julie Soutourina
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 262-274