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Showing 1–9 of 9 results
Advanced filters: Author: Julien Colombelli Clear advanced filters
  • Bladder cancer treatment suffers from low therapeutic efficacy. Here the authors present radioactive 131I-labelled urease-powered nanobots that exhibit enhanced accumulation at the tumour site, enabling effective radionuclide therapy at low doses as an alternative treatment option for bladder cancer.

    • Cristina Simó
    • Meritxell Serra-Casablancas
    • Samuel Sánchez
    ResearchOpen Access
    Nature Nanotechnology
    Volume: 19, P: 554-564
  • Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro platform representing tumour/stroma interface and demonstrate how modulation by IL2 may allow immune cells to overcome stromal barriers.

    • Alice Perucca
    • Andrea Gómez Llonín
    • Anna Labernadie
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • A poor prognosis gene programme in patients with colorectal cancer is expressed by a unique tumour cell population that we name high-relapse cells (HRCs), and ablation of cells expressing the HRC marker EMP1 or neoadjuvant immunotherapy prevented metastatic recurrence in mice.

    • Adrià Cañellas-Socias
    • Carme Cortina
    • Eduard Batlle
    Research
    Nature
    Volume: 611, P: 603-613
  • Wound repair is thought to involve cell migration and the contraction of a tissue-level biopolymer ring—invoking analogy with the pulling of purse strings. Traction-force measurements now show that this ring engages the tissue's surroundings to steer migration, prompting revision of the purse-string mechanism.

    • Agustí Brugués
    • Ester Anon
    • Xavier Trepat
    Research
    Nature Physics
    Volume: 10, P: 683-690
  • The regulation of lumen formation and dimension is a key question in organ morphogenesis. Using the zebrafish inner ear as a model, here the authors show that the growth of a cavity depends on epithelial thinning and mitotic cell rounding.

    • Esteban Hoijman
    • Davide Rubbini
    • Berta Alsina
    Research
    Nature Communications
    Volume: 6, P: 1-13
  • Poly-ADP-ribosylation is a post-translational modification catalyzed by enzymes such as PARP1, which responds to metabolic and genotoxic stress. Now macrodomain-containing proteins are shown to rapidly move to PARP1 activation sites, and recruitment of the macrodomain-containing histone macroH2A1.1 results in local chromatin changes.

    • Gyula Timinszky
    • Susanne Till
    • Andreas G Ladurner
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 923-929