Individualized drug therapy requires physicians to be able to accurately predict an individual's response to a drug. 'Pharmacogenetics' is the study of the role of inheritance in variation in drug response phenotypes. Pharmacogenetics is now moving genome-wide to become 'pharmacogenomics'. This article reviews the development, promise and challenges of pharmacogenomics, using examples of drugs used to treat or prevent cardiovascular disease.
- Naveen L. Pereira
- Richard M. Weinshilboum
