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Showing 1–5 of 5 results
Advanced filters: Author: Jumin Geng Clear advanced filters

  • Mixing antigens with liposomes containing cobalt porphyrin leads to the spontaneous formation of a malaria nanovaccine with increased uptake by phagocytic antigen-presenting cells, boosting the production of long-lasting functional antibodies in mice and rabbits.

    • Wei-Chiao Huang
    • Bingbing Deng
    • Jonathan F. Lovell
    Research
    Nature Nanotechnology
    Volume: 13, P: 1174-1181

  • Lipid bilayers containing porphyin-phospholipid that is chelated with cobalt have been shown to capture his-tagged proteins and peptides. This method offers a simple route for functionalizing pre-formed lipid bilayers without disrupting their integrity. Using this approach homing peptides were attached to cargo-loaded liposomes to enable tumour targeting, and an HIV-derived protein fragment elicited antibodies following binding to immunogenic liposomes.

    • Shuai Shao
    • Jumin Geng
    • Jonathan F. Lovell
    Research
    Nature Chemistry
    Volume: 7, P: 438-446

  • The delivery of therapeutics using an external trigger is an attractive route for the improvement of targeted disease treatment. Here, the authors have discovered a porphyrin–phospholipid liposome for light-controlled membrane permeabilization and use the system to deliver an anticancer drug in vivo.

    • Kevin A. Carter
    • Shuai Shao
    • Jonathan F. Lovell
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11

  • The excipients used to solubilise hydrophobic drugs sometimes interfere with drug behaviour or induce adverse side effects once injected. Here, the authors use a low-temperature process to obtain surfactant-stripped micelles with high drug concentration for delivery of a wide range of hydrophobic cargoes.

    • Yumiao Zhang
    • Wentao Song
    • Jonathan F. Lovell
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9