Targeted protein degradation harnessing the ubiquitin system is a groundbreaking modality in drug discovery. Here, the authors identify cellular signaling pathways, such as PARG, PERK, or HSP90, that modulate the targeted degradation of the anticancer targets such as BRD4 induced by PROTACs.
- Yuki Mori
- Yoshino Akizuki
- Fumiaki Ohtake
