Wang et al. find that deletion of FIP200, a protein essential for autophagy, leads to deficits in the maintenance and differentiation of postnatal neural stem cells (NSC). These effects are rescued by an antioxidant treatment, suggesting that FIP200-mediated autophagy regulates neurogenesis by controlling the oxidative state of NSC.
- Chenran Wang
- Chun-Chi Liang
- Jun-Lin Guan
