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After complete spinal cord injury, spinal segments below the lesion maintain inter-segmental communication via the intraspinal propriospinal network. Here, the authors show that neurons in these circuits can be chemogenetically modulated to improve locomotor function in mice after spinal cord injury.

CRISPR-Cas9 genome editing systems have great potential in cancer therapy. Here the authors report a gene-editing delivery system using functionalized nanovesicles derived from E. coli protoplasts to encapsulate Cas9-sgRNA ribonucleoprotein for the selective targeting of Pik3cg in tumor associated macrophages.

Spinon excitations of a Kagome quantum spin liquid are expected to give rise to a magnetic continuum in Raman spectroscopy. Here, the authors report a magnetic Raman continuum in the Kagome spin liquid candidate Cu₃Zn(OH)₆FBr, in contrast to a sharp magnon Raman peak in the Kagome antiferromagnet EuCu₃(OH)₆Cl₃.

The mechanistic involvement of sonic hedgehog signaling in nonalcoholic steatohepatitis is not clear. Here, the authors show that sonic hedgehog protein regulates the stability of HSP90β, enabling hepatocytes to secrete exosomes containing miR-28-5-p to promote NASH development.

Tunability of ferroelectric domain structure is significant in ferroelectric materials. Here, the authors present in-plane ferroelectricity in 2D Bi₂TeO₅ in which the ferroelectric domain size and shape can be continuously tuned by the Bi/Te ratio.

Here the authors demonstrate that Hawaiian lavas are formed by partial melting of mantle peridotite with subsequent fractionation of clinopyroxene and garnet in the deep magma chamber (90 km) and reequilibration with harzburgite at a shallower depth (<60 km).

Rational design of efficient electrocatalysts for oxygen evolution reaction is critical for water-alkali electrolysis. Here, the authors fabricate a NiMoN/NiFe layered double hydroxide and show the accelerated oxygen evolution kinetics are due to the heterointerface.

Symptom recovery is induced by a balanced “arms race” between viruses and plants. Here, the authors show that a small peptide mediates autophagic degradation of viral silencing suppressors to reach the balance of virus pathogenicity and plant immunity.

Short-wavelength spin waves with high group velocity are one of the key ingredients for the spin-wave based memory-logics. Here the authors demonstrate the propagation of spin waves with wavelength down to 50 nm and group velocity up to 2600 m s⁻¹ using ferromagnetic nanowires grown on a thin Y₃Fe₅O₁₂ film strip structure.

Electron filling causes a reduction of the chemical potential in (Sr_1−x La_x)₃Ir₂O₇, which suggests negative electronic compressibility. Studying the concomitant change of the bandgap provides insight into the physical mechanism behind this effect.

Thiopeptides such as nosiheptide are clinically-interesting antimicrobial natural products. Here the authors show the functional dissection of a series of enzymes involved in nosiheptide biosynthesis, revealing a unique biosynthetic pathway that centers on a previously-unknown carrier protein.

The early evolution of the deuterostomes is not well resolved. Here, Topper and colleagues investigate the early Cambrian metazoan Yanjiahella biscarpa, concluding that it is a stem echinoderm, is among the oldest known deuterstomes, and supports an ancestral enteropneust body plan in hemichordates.

Focused light beams can be used as optical tweezers for manipulating small dielectric particles, but they normally repel metallic ones. By exploiting surface plasmons excited by a radially polarized beam, Min et al.show that it is possible to trap metallic particles with diameters up to 2.2 μm.

Using direct intracranial recordings and modern speech AI models, Li and colleagues show representational and computational similarities between deep neural networks for self-supervised speech learning and the human auditory pathway.

Through-plane conductivity in anion-exchange membranes is beneficial for their use in fuel cells as it aids movement of ions from cathode to anode. Liu and colleagues use ferrocenium polymers and an applied magnetic field to orient ion channels appropriately and achieve improvements in stability by formation of magnetically induced mixed-valence states.

Two variants of the adeno-associated virus serotype 9 engineered to display specific cell-penetrating peptides on the capsid show enhanced transduction of cells of the central nervous system in small and large animals.

Long non-coding RNAs (lncRNA) are known to regulate human embryonic stem cell (hESC) self-renewal. Here, the authors identify lncRNA growth-arrest-specific transcript 5 (GAS5) that regulates pluripotency via modulation of NODAL signalling to maintain self-renewal in hESCs.

The single crystals of lithium rare earth fluorides exhibit remarkable magnetocaloric performance with a record-high entropy change of 16.73 J kg^-1 K^-1 achieved under a very small magnetic field of 5 kOe.

The antiferromagnetic topological insulator MnBi₂Te₄ exhibits Chern and axion insulator phases at low magnetic field; however, its behaviour in high magnetic field has remained unexplored. Here, using transport measurements at high magnetic field, the authors report a zero Hall plateau composed of two counter-propagating edge channels.

Electrochemical conversion of CO₂ into value-added chemicals holds promise to enable the transition to carbon neutrality, but enhancing the selectivity toward a specific hydrocarbon product remains a challenging task. Now, the authors present a Cu–polyamine hybrid catalyst that achieves Faradaic efficiency of 87% for ethylene and full-cell energy efficiency of 50%.

Efficient production of benzene from lignin is attractive and of great importance, but has not been realized. Here, the authors develop a strategy to transform lignin into benzene over a RuW/zeolite catalyst in water, and the yield of benzene can be as high as 18.8% on lignin weight basis.

Qiang Xu and colleagues sequence four citrus species de novo, along with 100 accessions, including primitive, wild and cultivated citrus. Their genomic analyses associate the CitRWP gene with polyembryony and suggest that regions harboring energy- and reproduction-associated genes are probably under selection in cultivated citrus.

Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.

Yu and colleagues report the formation of migrasomes during zebrafish gastrulation. Migrasomes provide signalling molecules to guide the migration of dorsal forerunner cells, thus controlling organ morphogenesis.

The rapid growth of South–South trade reflects a new phase of globalization. Here the authors show that some energy-intensive production activities, particularly raw materials and intermediate goods, and related CO₂ emissions are relocating from China and India to other developing countries.

Climate dynamics in Earth’s distant history can provide important forecasting for future changes, but uncertainties in proxy-derived carbon dioxide results are common. Here Da and colleagues present a refined paleosol proxy for carbon dioxide reconstruction, and report persistently low levels ( < 300 ppm) throughout the Pleistocene interglacials.

Proton exchange membranes with short-pathway through-plane proton conductivity are attractive for proton exchange membrane fuel cells. Here the authors align proton conducting channels orthogonal to the plane of composite proton exchange membranes using a magnetic field for improved fuel cell performance.

To trace the sources of Black Carbon being transported into the Tibetan Plateau is crucial for guiding an effective mitigation strategy. Here the authors utilized the adjoint of the Goddard Earth Observing System-Chem model and find that international trade aggravates the BC pollution over the HTP glacier regions and may cause significant climate change.

High-salt intake can promote pro-inflammatory responses associated with pathological conditions. However, here, the authors show that high-salt diet may have an antitumor protective role by modulating the accumulation and phenotype of myeloid derived suppressor cells and enhancing immunosurveillance.