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Showing 1–3 of 3 results
Advanced filters: Author: Junco S. Warren Clear advanced filters

  • Long noncoding RNAs (lncRNAs) have been shown to play a role in cardiac physiology and disease. Here the authors identify the lncRNA Caren as a cytoplasmic RNA that decreases the translation of a distant gene encoding Hint1, thereby maintaining cardiomyocyte function due to inactivation of the DNA damage response and activation of mitochondrial bioenergetics.

    • Michio Sato
    • Tsuyoshi Kadomatsu
    • Yuichi Oike
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Song and colleagues show that FDA-approved cough suppressant dextromethorphan could be used as an agonist of sigma non-opioid intracellular receptor 1 (SIGMAR1) to normalize the action potential in human cellular models and a mouse model of Timothy syndrome, a congenital disease with no available treatment. The researchers also show that dextromethorphan normalizes the action potential in human cellular models of two additional inherited cardiac arrhythmias: long QT syndrome types 1 and 2, which are caused by mutations in different genes.

    • LouJin Song
    • Ramsey Bekdash
    • Masayuki Yazawa
    Research
    Nature Cardiovascular Research
    Volume: 1, P: 142-156