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Showing 1–13 of 13 results
Advanced filters: Author: Junedh M. Amrute Clear advanced filters

  • Amrute, Lai et al. performed single-nucleus RNA sequencing and compared the cellular and transcriptomic features of hearts from non-diseased donors, from patients with heart failure who recovered systolic function after left ventricular assist device implantation and from patients who did not recover. The analyses identified cell-type-specific signatures of recovery and revealed the downregulation of RUNX1 expression in macrophages and fibroblasts as a predictor of recovery, as confirmed by in silico simulations and re-analysis of data from a mouse model of cardiac functional recovery.

    • Junedh M. Amrute
    • Lulu Lai
    • Kory J. Lavine
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 399-416

  • A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling to cardiac fibroblasts, highlighting a role for immunomodulators in targeting cardiac fibrosis.

    • Junedh M. Amrute
    • Xin Luo
    • Kory J. Lavine
    Research
    Nature
    Volume: 635, P: 423-433

  • Heart failure can be caused by cardiac fibroblasts replacing myocytes. Here, the authors use functional genomic data from fibroblasts, genetic signals enriched in people with heart disease, and gene perturbation analyses to link disease-associated regulatory elements to protein-coding genes.

    • Richard Gill
    • Daniel R. Lu
    • Yi-Hsiang Hsu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Infection with SARS-CoV-2 results in activation of multiple immune cell types in situ but also in the peripheral blood compartment. Here the authors apply single cell sequencing and machine learning to characterise the response and link this to confer prognostic indicators in critically ill COVID-19 patients.

    • Junedh M. Amrute
    • Alexandra M. Perry
    • Ashley L. Steed
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Jimenez et al. show that CD40 agonists can induce myocardial inflammation by activating cardiac macrophages and CD8+ T cells, sensitizing the heart to secondary injury and promoting adverse remodeling.

    • Jesus Jimenez
    • Junedh Amrute
    • Kory J. Lavine
    Research
    Nature Cardiovascular Research
    Volume: 4, P: 458-472

  • SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascular disease.

    • Jared S. Elenbaas
    • Upasana Pudupakkam
    • Nathan O. Stitziel
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • A time-resolved high-resolution map of human cardiac remodelling after myocardial infarction, integrating single-cell transcriptomic, chromatin accessibility and spatial transcriptomic data, provides a valuable resource for the field.

    • Christoph Kuppe
    • Ricardo O. Ramirez Flores
    • Rafael Kramann
    Research
    Nature
    Volume: 608, P: 766-777

  • Secretome analysis of infarct-activated cardiac fibroblasts reveals the dynamic secretion of numerous paracrine factors in cardiac healing; this secretome atlas might serve as resource for new diagnostic and therapeutic targets.

    • Jasmin Bahr
    • Gereon Poschmann
    • Jürgen Schrader
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-18

  • Koenig et al. present integrated single-cell and single-nucleus RNA-sequencing data of cardiac samples obtained from 27 healthy donors and 18 individuals with dilated cardiomyopathy. This extensive resource provides insights on cell composition and gene expression changes driven by the disease status, sex or age of the patients.

    • Andrew L. Koenig
    • Irina Shchukina
    • Kory J. Lavine
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 263-280