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Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes

Authors develop a quantitative super-resolution proximity labeling technique utilizing stable isotope-coded probes (ICAX). ICAX characterizes the dynamics of the proteome within the mitochondrial intracristal space.

Myeong-Gyun Kang
Sanghee Shin
Hyun-Woo Rhee
ResearchOpen Access20 Aug 2025
Nature Communications

Volume: 16, P: 1-15
A pan-specific antibody for direct detection of protein histidine phosphorylation

Studies of histidine phosphorylation have been limited owing to a lack of appropriate tools. The synthesis of a stable phosphohistidine mimic now leads to a pan antibody, enabling detection and further functional investigations of this little-known post-translational modification.

Jung-Min Kee
Rob C Oslund
Tom W Muir
Research26 May 2013
Nature Chemical Biology

Volume: 9, P: 416-421
Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

The daphnane diterpene orthoesters constitute a structurally fascinating family of natural products that exhibit remarkable and potent biological activities. A gateway strategy designed to provide general synthetic access to and biological evaluation of natural and non-natural daphnanes is described and used for yuanhuapin analogues.

Paul A. Wender
Nicole Buschmann
Kate E. Longcore
Research19 Jun 2011
Nature Chemistry

Volume: 3, P: 615-619
Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

Bisphosphoglycerate mutase (BPGM) drives phosphoglycerate mutase 1 (PGAM1) phosphorylation, which is required for glycolytic flux. Loss of BPGM is partially compensated by 1,3-BPG directly phosphorylating PGAM1, sustaining glycolytic flux but diverting metabolites for serine synthesis.

Rob C Oslund
Xiaoyang Su
Joshua D Rabinowitz
Research07 Aug 2017
Nature Chemical Biology

Volume: 13, P: 1081-1087
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes

A pan-specific antibody for direct detection of protein histidine phosphorylation

Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

AI is a viable alternative to high throughput screening: a 318-target study

Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

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