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Author Correction: Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress

Xihui Liu
Suryavathi Viswanadhapalli
Ganesh V. Raj
Amendments and CorrectionsOpen Access20 May 2024
Nature Cancer

Volume: 5, P: 953
Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress

Raj and colleagues show that ERX-41 inhibits lipase-independent functions of LIPA and induces ER stress in different tumor types, providing a therapeutic strategy in PDX models of pancreas, ovarian and triple-negative breast cancer.

Xihui Liu
Suryavathi Viswanadhapalli
Ganesh V. Raj
ResearchOpen Access02 Jun 2022
Nature Cancer

Volume: 3, P: 866-884
Peptidomimetic targeting of critical androgen receptor–coregulator interactions in prostate cancer

Androgen receptor signalling plays an important role in driving prostate cancer progression. Here the authors design a peptidomimetic that blocks the interaction between the androgen receptor and its coactivator PELP1, and show that the drug slows prostate cancer cell growth in a xenograft model.

Preethi Ravindranathan
Tae-Kyung Lee
Ganesh V. Raj
Research28 May 2013
Nature Communications

Volume: 4, P: 1-11
The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Adenocarcinoma and squamous cell carcinoma are distinct subtypes of non-small cell lung cancer. Here, the authors show that increased glycolytic flux, via increased glucose transporter Glut1 expression, is a core metabolic feature of squamous cell carcinoma that renders it sensitive to glycolysis inhibition.

Justin Goodwin
Michael L. Neugent
Jung-whan Kim
ResearchOpen Access26 May 2017
Nature Communications

Volume: 8, P: 1-16

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Author Correction: Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress

Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress

Peptidomimetic targeting of critical androgen receptor–coregulator interactions in prostate cancer

The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

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