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Showing 1–3 of 3 results
Advanced filters: Author: Jungsan Sohn Clear advanced filters

  • AIM2-ASC inflammasomes are filamentous signalling platforms that play a central role in host innate defence. Here, the authors present the filament cryo-EM structure of the inflammasome receptor AIM2, which is very similar to the adaptor ASC filament structure. By employing Rosetta and Molecular Dynamics simulations the authors provide further insights into the directionality and recognition mechanisms of the individual AIM2 and ASC filaments, which is further validated with biochemical and cellular experiments.

    • Mariusz Matyszewski
    • Weili Zheng
    • Jungsan Sohn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The AIM2 inflammasome complex is essential for defence against a number of human pathogens but how it assembles upon recognition of foreign DNA remains incompletely understood. Here Morrone et al.suggest the AIM2 pyrin domain acts in both DNA binding and filament assembly to generate a structural template for complex assembly.

    • Seamus R. Morrone
    • Mariusz Matyszewski
    • Jungsan Sohn
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13