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The activated conformation of integrin β₇ is a novel multiple myeloma–specific target for CAR T cell therapy

Hosen et al. identify an active conformation of integrin beta-7 as a cancer-associated antigen in multiple myeloma, and engineer a CAR-T cell that shows efficacy against MM in a mouse model. These findings describe the first conformation-specific CAR-T cell and highlight the potential of conformational targets in cancer immunotherapy.

Naoki Hosen
Yukiko Matsunaga
Atsushi Kumanogoh
Research06 Nov 2017
Nature Medicine

Volume: 23, P: 1436-1443
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase
Takumi Hirata
Masayuki Yamamoto
ResearchOpen Access13 Aug 2025
Hypertension Research

Volume: 48, P: 2606-2617
Correlation between choline kinase alpha expression and ¹¹C-choline accumulation in breast cancer using positron emission tomography/computed tomography: a retrospective study

Akane Ozawa
Masako Iwasaki
Ukihide Tateishi
ResearchOpen Access17 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Comparable survival outcomes with haploidentical stem cell transplantation and cord blood transplantation

Junichi Sugita
Yoshiko Atsuta
Takanori Teshima
Research20 Aug 2022
Bone Marrow Transplantation

Volume: 57, P: 1681-1688
Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis

Toshihiko Ishimitsu
Tomoko Kameda
Hiroaki Matsuoka
Research01 Jul 2007
Hypertension Research

Volume: 30, P: 621-626
Robotic crowd biology with Maholo LabDroids

Nozomu Yachie
Koichi Takahashi
Tohru Natsume
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 310-312
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

While transcranical direct current stimulation (tDCS) is used in clinical setting, its cellular mechanism of action is unclear. Here, Hajime Hirase and colleagues visualize cellular response in mouse brain to tDCS and show robust astrocyte activation that coincide with plasticity changes.

Hiromu Monai
Masamichi Ohkura
Hajime Hirase
ResearchOpen Access22 Mar 2016
Nature Communications

Volume: 7, P: 1-10
Layer V cortical neurons require microglial support for survival during postnatal development

In this study, the authors show that layer V projection neurons require the presence of subcortical CX3CR1-positive microglia for survival. IGF1 secretion from these microglia appears to be necessary for this trophic effect. Inhibition of the microglial cell activation abrogates IGF1 secretion and compromises neuronal survival.

Masaki Ueno
Yuki Fujita
Toshihide Yamashita
Research24 Mar 2013
Nature Neuroscience

Volume: 16, P: 543-551
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
A severe case of cardiospondylocarpofacial syndrome with a novel MAP3K7 variant

Hiromi Nyuzuki
Junichi Ozawa
Takeshi Ikeuchi
ResearchOpen Access22 Feb 2024
Human Genome Variation

Volume: 11, P: 1-3
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Correction To: Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation

Yukio Arai
Masato Ito
Fumihiko Namba
Amendments and Corrections12 Jun 2023
Pediatric Research

Volume: 94, P: 1582
Impact of being large-for-gestational-age on neonatal mortality and morbidities in extremely premature infants

Junichi Ozawa
Kosuke Tanaka
Fumihiko Namba
Research27 Jan 2021
Pediatric Research

Volume: 90, P: 910-916
Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation

Yoshiko Atsuta
Junichi Sugita
Takanori Teshima
Research12 Sept 2022
Bone Marrow Transplantation

Volume: 57, P: 1781-1787
Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation

Yukio Arai
Masato Ito
Fumihiko Namba
Research02 Oct 2019
Pediatric Research

Volume: 87, P: 494-500
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Increased Ca_V1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly

Junichi Ozawa
Seiko Ohno
Minoru Horie
ResearchOpen Access08 Nov 2022
Scientific Reports

Volume: 12, P: 1-10
Human leukocyte antigen (HLA) haplotype matching in unrelated single HLA allele mismatch bone marrow transplantation

Akihisa Kawajiri
Takakazu Kawase
Junya Kanda
Research21 Jan 2022
Bone Marrow Transplantation

Volume: 57, P: 407-415
Low-dose antithymocyte globulin inhibits chronic graft-versus-host disease in peripheral blood stem cell transplantation from unrelated donors

Souichi Shiratori
Junichi Sugita
Takanori Teshima
Research07 May 2021
Bone Marrow Transplantation

Volume: 56, P: 2231-2240
An NGS-based genotyping in LQTS; minor genes are no longer minor

Seiko Ohno
Junichi Ozawa
Minoru Horie
Research17 Jul 2020
Journal of Human Genetics

Volume: 65, P: 1083-1091
Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist

Wenyu Miao
Katsuya Sakai
Kunio Matsumoto
ResearchOpen Access07 Nov 2018
Scientific Reports

Volume: 8, P: 1-11
Denosumab for dialysis patients with osteoporosis: A cohort study

Kyohei Kunizawa
Rikako Hiramatsu
Kenmei Takaichi
ResearchOpen Access12 Feb 2020
Scientific Reports

Volume: 10, P: 1-9
Gastric cancer biomarker analysis in patients treated with different adjuvant chemotherapy regimens within SAMIT, a phase III randomized controlled trial

Takashi Oshima
Akira Tsuburaya
Shiro Tanaka
ResearchOpen Access20 May 2022
Scientific Reports

Volume: 12, P: 1-14
Elavl3 is essential for the maintenance of Purkinje neuron axons

Yuki Ogawa
Kyoko Kakumoto
Hirotaka James Okano
ResearchOpen Access09 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
The serum thioredoxin-1 levels are not associated with bronchopulmonary dysplasia and retinopathy of prematurity

Mitsuhiro Haga
Nobuhiko Nagano
Fumihiko Namba
ResearchOpen Access16 Feb 2024
Pediatric Research

Volume: 96, P: 1275-1282
Comparison of fludarabine, a myeloablative dose of busulfan, and melphalan vs conventional myeloablative conditioning regimen in patients with relapse and refractory acute myeloid leukemia in non-remission status

Yoshimitsu Shimomura
Masahiko Hara
Masamitsu Yanada
Correspondence21 Jun 2021
Bone Marrow Transplantation

Volume: 56, P: 2302-2304

Search

The activated conformation of integrin β₇ is a novel multiple myeloma–specific target for CAR T cell therapy

Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Correlation between choline kinase alpha expression and ¹¹C-choline accumulation in breast cancer using positron emission tomography/computed tomography: a retrospective study

Comparable survival outcomes with haploidentical stem cell transplantation and cord blood transplantation

Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis

Robotic crowd biology with Maholo LabDroids

New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

Layer V cortical neurons require microglial support for survival during postnatal development

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

A severe case of cardiospondylocarpofacial syndrome with a novel MAP3K7 variant

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Correction To: Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation

Impact of being large-for-gestational-age on neonatal mortality and morbidities in extremely premature infants

Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation

Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Increased Ca_V1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly

Human leukocyte antigen (HLA) haplotype matching in unrelated single HLA allele mismatch bone marrow transplantation

Low-dose antithymocyte globulin inhibits chronic graft-versus-host disease in peripheral blood stem cell transplantation from unrelated donors

An NGS-based genotyping in LQTS; minor genes are no longer minor

Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist

Denosumab for dialysis patients with osteoporosis: A cohort study

Gastric cancer biomarker analysis in patients treated with different adjuvant chemotherapy regimens within SAMIT, a phase III randomized controlled trial

Elavl3 is essential for the maintenance of Purkinje neuron axons

The serum thioredoxin-1 levels are not associated with bronchopulmonary dysplasia and retinopathy of prematurity

Comparison of fludarabine, a myeloablative dose of busulfan, and melphalan vs conventional myeloablative conditioning regimen in patients with relapse and refractory acute myeloid leukemia in non-remission status

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