Nature Search

Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Fan et al. describe DF-003, an alpha-kinase 1 (ALPK1) inhibitor that targets the root cause of the rare genetic disease ROSAH syndrome, demonstrating the ability of DF-003 to inhibit ocular inflammatory pathology in ROSAH model mice.

Jieqing Fan
Danyang Liu
Cong Xu
ResearchOpen Access09 Sept 2025
Nature Communications

Volume: 16, P: 1-15
How growing up without siblings affects the adult brain and behaviour in the CHIMGEN cohort

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Jie Tang
Jing Zhang
Yue Wu
Research31 Mar 2025
Nature Human Behaviour

Volume: 9, P: 1005-1022
Distinct effects of early-stage and late-stage socioeconomic factors on brain and behavioral traits

Socioeconomic status is multidimensional and can change over time. Xu, Lui, Ji et al. found dimension-specific, late-stage-specific and change-specific socioeconomic effects on brain, cognition, personality and emotion.

Qiang Xu
Su Lui
Yue Wu
Research24 Feb 2025
Nature Neuroscience

Volume: 28, P: 676-687
Cross-ancestry genome-wide association studies of brain imaging phenotypes

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

Jilian Fu
Quan Zhang
Yue Wu
Research29 May 2024
Nature Genetics

Volume: 56, P: 1110-1120
Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes

Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant–trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.

Nana Liu
Longjiang Zhang
Yue Wu
Research19 Jun 2023
Nature Genetics

Volume: 55, P: 1126-1137
Dual stimuli-responsive rotaxane-branched dendrimers with reversible dimension modulation

Mechanically interlocked molecules are extensively applied as artificial molecular machines but rotaxane-branched dendrimers are rarely explored because of synthetic challenges. Here the authors present the construction of dual stimuli-responsive rotaxane-branched dendrimer which can be stimulated by DMSO or acetate ions.

Xu-Qing Wang
Wei Wang
Hai-Bo Yang
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-11
Solidified glomerulosclerosis, identified using single glomerular proteomics, predicts end-stage renal disease in Chinese patients with type 2 diabetes

Lijun Zhao
Fang Liu
Mark E. Cooper
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-14
The role of autophagy in colitis-associated colorectal cancer

Yuhui Wu
Junlin Yao
Weidong Han
ReviewsOpen Access30 Nov 2018
Signal Transduction and Targeted Therapy

Volume: 3, P: 1-11
Manipulating the air-filled zebrafish swim bladder as a neutrophilic inflammation model for acute lung injury

Yuefei Zhang
Hongcui Liu
Yuehai Ke
ResearchOpen Access10 Nov 2016
Cell Death & Disease

Volume: 7, P: e2470

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