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Integrated extracellular microRNA profiling for ovarian cancer screening

Screening methods for early detection of ovarian cancer is technically difficult. Here, the authors investigated circulating microRNA in human blood serum and developed a model using 10 microRNAs to discern between ovarian cancer and being ovarian tumors, solid tumors, and non-cancer patients.

Akira Yokoi
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access17 Oct 2018
Nature Communications

Volume: 9, P: 1-10
Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

The relevance of cell competition in intestinal epithelial carcinogenesis remains to be explored. Here, the authors find aberrant Wnt activation in RasV12-transformed cells reverses the directionality of cell extrusion mediated by cell competition in intestinal epithelium, causing infiltration into basal lamina rather than apical elimination of transformed cells and consequent development of invasive carcinomas.

Kazuki Nakai
Hancheng Lin
Shunsuke Kon
ResearchOpen Access03 Nov 2023
Nature Communications

Volume: 14, P: 1-17
A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes

Sarcomas are rare malignant tumours of bone and soft tissue whose diagnosis remain difficult. Here, the authors analyse serum samples from over 1000 patients and using separate discovery, training and validation cohorts, identify and validate a 7-microRNA index that distinguishes malignant sarcomas from benign disease.

Naofumi Asano
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-10
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Structural insight into GPR55 ligand recognition and G-protein coupling

Ruixue Xia
Qingning Yuan
Yuanzheng He
CorrespondenceOpen Access31 Oct 2024
Cell Research

Volume: 35, P: 76-79
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17

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Integrated extracellular microRNA profiling for ovarian cancer screening

Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Structural insight into GPR55 ligand recognition and G-protein coupling

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

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