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Showing 1–5 of 5 results
Advanced filters: Author: Justin H. Letendre Clear advanced filters

  • Kiwimagi & Letendre et al. present a workflow to quantitatively define recombinase-based digitizer and predict responses to different input signals. With a mechanistic/phenotypic model that can predict circuit performance, they generate a synthetic cell-cell communication device that amplifies a synNotch output signal.

    • Katherine A. Kiwimagi
    • Justin H. Letendre
    • Ron Weiss
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-12

  • The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

    • Sunil K. Ahuja
    • Muthu Saravanan Manoharan
    • Weijing He
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-31

  • The availability of high performance recombinases with low basal activity and high dynamic range is limited. Here the authors present a library of over 20 orthogonal split recombinases that can be induced by small molecules, light and temperature in vivo.

    • Benjamin H. Weinberg
    • Jang Hwan Cho
    • Wilson W. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • Cell-based transcriptional reporters are an invaluable part of highthroughput screening, but many such reporters have weak or transient responses. Here, the authors describe a digitizer circuit for amplifying reporter activity, increasing sensitivity, and retaining memory of pathway activation.

    • Nicole M. Wong
    • Elizabeth Frias
    • Wilson W. Wong
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218