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Showing 1–6 of 6 results
Advanced filters: Author: Justyna Sawa Clear advanced filters

  • The Cvt pathway in yeast operates constitutively, but the mechanism by which non-cargo material is excluded from the vacuole is incompletely defined. Martens and colleagues show that cargo binding to the cargo receptor Atg19 exposes further Atg8 binding sites on the receptor, which draws the isolation membrane around the autophagic cargo and prevents inclusion of non-cargo material in autophagosomes.

    • Justyna Sawa-Makarska
    • Christine Abert
    • Sascha Martens
    Research
    Nature Cell Biology
    Volume: 16, P: 425-433

  • Mitophagy is an important quality control pathway. Here, the authors identify the mechanisms enabling the TBK1 adaptors NAP1 and SINTBAD to prevent hyperactivation of PINK1/Parkin mitophagy while promoting the pathway once set in motion.

    • Elias Adriaenssens
    • Thanh Ngoc Nguyen
    • Sascha Martens
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1717-1731

  • HtrA proteins have chaperone and protease activities, but how they bind and fold their substrates is poorly understood. New cryo-EM analyses of a protease-defective bacterial DegQ mutant in complex with several different substrates provide a structural model of HtrA proteins in their chaperone mode.

    • Hélène Malet
    • Flavia Canellas
    • Helen R Saibil
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 152-157

  • HtrA proteases can switch between active and inactive states to adjust their enzymatic activity to the needs of the cell. Structural and biochemical studies of bacterial DegP show that peptide binding to the PDZ domain of DegP induces the conversion of resting hexameric DegP into active higher-order DegP complexes. A specific protease loop in the 12- and 24-meric DegP particles senses the relocated PDZ domain, inducing conformational changes that ultimately result in protease activation.

    • Tobias Krojer
    • Justyna Sawa
    • Tim Clausen
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 844-852