Nature Search

Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis

A mode of bidirectional microglia–neuron crosstalk through Hex–GM2–MGL2 and centred around GM2 ganglioside turnover is essential for homeostatic regulation of central nervous system membrane components.

Maximilian Frosch
Takashi Shimizu
Marco Prinz
ResearchOpen Access06 Aug 2025
Nature

P: 1-12
Proteomic analysis of the urothelial cancer landscape

Urothelial cancer is a challenging disease and an emerging field for targeted therapies. Here, the authors optimize clinical proteomics to provide proteome-level data on tumor specificity and identify robust prognostic subtypes with predictive information for repurposed drug candidates.

Franz F. Dressler
Falk Diedrichs
Ákos Végvári
ResearchOpen Access27 May 2024
Nature Communications

Volume: 15, P: 1-19
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.

Matthias Kettwig
Katharina Ternka
Jutta Gärtner
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Jieqi Wang
Jan Eike Wegener
Andrew A. Pieper
Research20 May 2015
Nature

Volume: 521, P: E1-E4
Manganese-driven CoQ deficiency

Across phylae, excess manganese disrupts energy metabolism by unclear mechanisms. Here, Diessl et al. report that failure of mitochondrial bioenergetics upon manganese overload is due to mismetallation of a diiron enzyme crucial for CoQ biosynthesis

Jutta Diessl
Jens Berndtsson
Sabrina Büttner
ResearchOpen Access13 Oct 2022
Nature Communications

Volume: 13, P: 1-14
Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

Drugs targeting dysregulated ERK1/2 signaling can cause severe cardiac side effects, precluding their wide therapeutic application. Here, a new and cardio-safe targeting strategy is presented that interferes with ERK dimerization to prevent pathological ERK1/2 signaling in the heart and cancer.

Angela Tomasovic
Theresa Brand
Kristina Lorenz
ResearchOpen Access07 Apr 2020
Nature Communications

Volume: 11, P: 1-16
Microbial functional changes mark irreversible course of Tibetan grassland degradation

The Tibetan Kobresia pastures store 2.5% of the world’s soil organic carbon. Here the authors show that soil degradation and microbial shifts may irreversibly diminish the carbon sink function and accelerate nutrient losses.

Andreas Breidenbach
Per-Marten Schleuss
Sandra Spielvogel
ResearchOpen Access13 May 2022
Nature Communications

Volume: 13, P: 1-10
Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection

Binding antibody levels correlate with protection against infection with the ancestral SARS-CoV-2 strain, but it is not clear whether this relationship extends to the Omicron variant. Here, the authors characterise antibody dynamics and their relationship with Omicron infection in a longitudinal cohort from Geneva, Switzerland.

Javier Perez-Saez
María-Eugenia Zaballa
Ania Wisniak
ResearchOpen Access26 May 2023
Nature Communications

Volume: 14, P: 1-9
Genome-wide association study reveals two new risk loci for bipolar disorder

Bipolar disorder (BD) is a severe mood disorder, which has been shown to have a large genetic component. Here the authors identify two previously unreported BD risk loci and provide further insights into the biological mechanisms underlying BD development.

Thomas W. Mühleisen
Markus Leber
Sven Cichon
Research11 Mar 2014
Nature Communications

Volume: 5, P: 1-8
PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome

Aurélie Caye-Eude
Grazia Fazio
Sabine Strehl
ResearchOpen Access19 Dec 2024
Leukemia

Volume: 39, P: 482-486
Dexamethasone Aggravates Hippocampal Apoptosis and Learning Deficiency in Pneumococcal Meningitis in Infant Rats

Stephen L Leib
Chris Heimgartner
Martin G Täuber
Research01 Sept 2003
Pediatric Research

Volume: 54, P: 353-357
TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer

Michael Guenther
Sai Agash Surendran
Steffen Ormanns
ResearchOpen Access04 May 2023
British Journal of Cancer

Volume: 129, P: 175-182
Protein nutrition governs within-host race of honey bee pathogens

Manuel Tritschler
Jutta J. Vollmann
Peter Neumann
ResearchOpen Access08 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Deep Visual Proteomics defines single-cell identity and heterogeneity

Deep Visual Proteomics combines machine learning, automated image analysis and single-cell proteomics.

Andreas Mund
Fabian Coscia
Matthias Mann
ResearchOpen Access19 May 2022
Nature Biotechnology

Volume: 40, P: 1231-1240
Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas

Helen Pasternack
Christiane Kuempers
Martin Reck
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-10
CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

Bianca Altvater
Sareetha Kailayangiri
Claudia Rossig
ResearchOpen Access30 Jun 2023
Cancer Gene Therapy

Volume: 30, P: 1355-1368
Poor outcome in hypoxic endometrial carcinoma is related to vascular density

Casper Reijnen
Willem Jan van Weelden
Johanna M. A. Pijnenborg
ResearchOpen Access23 Apr 2019
British Journal of Cancer

Volume: 120, P: 1037-1044
Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification

Emily F. Thompson
Jutta Huvila
Amy Jamieson
Research14 Oct 2022
Modern Pathology

Volume: 35, P: 1974-1982
pT3 colorectal cancer revisited: a multicentric study on the histological depth of invasion in more than 1000 pT3 carcinomas—proposal for a new pT3a/pT3b subclassification

Sebastian Foersch
Corinna Lang-Schwarz
Moritz Jesinghaus
ResearchOpen Access21 Jul 2022
British Journal of Cancer

Volume: 127, P: 1270-1278
L1CAM expression in endometrial carcinomas: an ENITEC collaboration study

Louis JM van der Putten
Nicole CM Visser
Johanna MA Pijnenborg
ResearchOpen Access09 Aug 2016
British Journal of Cancer

Volume: 115, P: 716-724
Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite instability but is prognostically inferior to hematoxylin–eosin-based morphologic parameters from the WHO classification

Björn Konukiewitz
Maxime Schmitt
Moritz Jesinghaus
ResearchOpen Access06 Oct 2021
British Journal of Cancer

Volume: 125, P: 1632-1646
Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential

Ivo Meinhold-Heerlein
Dirk Bauerschlag
Garret M Hampton
Research22 Nov 2004
Oncogene

Volume: 24, P: 1053-1065
Fibroblast growth factor receptor 1 amplification is a common event in squamous cell carcinoma of the head and neck

Friederike Göke
Maike Bode
Sven Perner
Research26 Apr 2013
Modern Pathology

Volume: 26, P: 1298-1306
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders

H Chang
N Hoshina
M Li
ResearchOpen Access10 Jan 2017
Molecular Psychiatry

Volume: 23, P: 400-412

Search

Microglia–neuron crosstalk through Hex–GM2–MGL2 maintains brain homeostasis

Proteomic analysis of the urothelial cancer landscape

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Wild-type microglia do not reverse pathology in mouse models of Rett syndrome

Manganese-driven CoQ deficiency

Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

Microbial functional changes mark irreversible course of Tibetan grassland degradation

Long term anti-SARS-CoV-2 antibody kinetics and correlate of protection against Omicron BA.1/BA.2 infection

Genome-wide association study reveals two new risk loci for bipolar disorder

PAX5::AUTS2 childhood B-ALL: a relapse-prone genetic subtype with frequent central nervous system involvement and a poor outcome

Dexamethasone Aggravates Hippocampal Apoptosis and Learning Deficiency in Pneumococcal Meningitis in Infant Rats

TPX2 expression as a negative predictor of gemcitabine efficacy in pancreatic cancer

Protein nutrition governs within-host race of honey bee pathogens

Deep Visual Proteomics defines single-cell identity and heterogeneity

Identification of molecular signatures associated with early relapse after complete resection of lung adenocarcinomas

CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering process

Poor outcome in hypoxic endometrial carcinoma is related to vascular density

Variability in endometrial carcinoma pathology practice: opportunities for improvement with molecular classification

pT3 colorectal cancer revisited: a multicentric study on the histological depth of invasion in more than 1000 pT3 carcinomas—proposal for a new pT3a/pT3b subclassification

L1CAM expression in endometrial carcinomas: an ENITEC collaboration study

Loss of CDX2 in colorectal cancer is associated with histopathologic subtypes and microsatellite instability but is prognostically inferior to hematoxylin–eosin-based morphologic parameters from the WHO classification

Molecular and prognostic distinction between serous ovarian carcinomas of varying grade and malignant potential

Fibroblast growth factor receptor 1 amplification is a common event in squamous cell carcinoma of the head and neck

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders

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