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Advanced filters: Author: Jyothi Rengarajan Clear advanced filters

Alveolar macrophages from persons with HIV mount impaired TNF signaling networks to M. tuberculosis infection

People living with HIV (PLWH) are at high risk of tuberculosis development after Mycobacterium tuberculosis (Mtb) infection. Here the authors compare single cell transcriptomics between BAL cells from PLWH on ART and healthy controls upon ex vivo Mtb infection and find impaired alveolar macrophage (AM) with reduced TNF expression and M1-AM interactions in PLWH.

Khanyisile Kgoadi
Prashant Bajpai
Jyothi Rengarajan
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-20
NFATc2 and NFATc3 regulate T_H2 differentiation and modulate TCR-responsiveness of naïve T_H cells

Jyothi Rengarajan
Betty Tang
Laurie H. Glimcher
Research10 Dec 2001
Nature Immunology

Volume: 3, P: 48-54
Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis

BCG, the only vaccine currently used against tuberculosis, confers only limited protection. Here the authors show that mucosal immunization of macaques with an attenuated strain of Mycobacterium tuberculosisconfers a high level of protection from a lethal challenge with the bacterium.

Deepak Kaushal
Taylor W. Foreman
Smriti Mehra
ResearchOpen Access13 Oct 2015
Nature Communications

Volume: 6, P: 1-14

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