Nature Search

An Immediate Effect of X-Radiation on Thymus Cells

D. K. MYERS
Research01 Jan 1965
Nature

Volume: 205, P: 365-367
Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex

Hung and colleagues show that ALK-mediated CDK9 activation increases homologous recombination repair and PARP inhibition resistance and propose combinatorial inhibition of ALK and PARP as therapeutically beneficial for treatment-resistant tumors.

Yu-Yi Chu
Mei-Kuang Chen
Mien-Chie Hung
ResearchOpen Access17 Oct 2022
Nature Cancer

Volume: 3, P: 1211-1227
Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment

Li Mao
Jin S. Lee
Waun K. Hong
Research01 Jun 1996
Nature Medicine

Volume: 2, P: 682-685
Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial

The combination of neoadjuvant nivolumab, ipilimumab and chemotherapy showed promising efficacy in patients with resectable non-small cell lung cancer, with higher tumor immune cell infiltration and tertiary lymphoid structures after treatment compared with neoadjuvant nivolumab plus chemotherapy.

Tina Cascone
Cheuk H. Leung
Boris Sepesi
ResearchOpen Access16 Mar 2023
Nature Medicine

Volume: 29, P: 593-604
Is Europa surface cracking due to thermal evolution?

A. A. Finnerty
G. A. Ransford
K. D. Collerson
Research01 Jan 1981
Nature

Volume: 289, P: 24-27
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics

Here, the authors find a decrease in hepatic phagocytic uptake of nanoparticles in old mice due to age-associated downregulation of the scavenger receptor MARCO, which led to improved tumour delivery and antitumour efficacy of cancer nanomedicine, showing the need to consider age as a factor in therapeutics.

Yifan Wang
Weiye Deng
Wen Jiang
Research18 Sept 2023
Nature Nanotechnology

Volume: 19, P: 255-263
Introducing metal–sulfur active sites in metal–organic frameworks via post-synthetic modification for hydrogenation catalysis

Metal–sulfur motifs are commonly found in enzymatic active sites and heterogeneous catalysis, but they remain underexplored in porous solids. Now, sulfur-based ligands have been incorporated into metal–organic frameworks through post-synthetic modifications. The resulting sulfide MOFs exhibit enhanced catalytic performance in the selective hydrogenation of nitroarenes compared with their parent MOFs containing terminal or bridging chloride and hydroxyl groups.

Haomiao Xie
Milad Ahmadi Khoshooei
Omar K. Farha
Research24 Jul 2025
Nature Chemistry

Volume: 17, P: 1514-1523
Short-term storage and wind power availability (reply)

M. B. ANDERSON
K. NEWTON
P. F. SCOTT
Research28 Jun 1979
Nature

Volume: 279, P: 818
A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma

Roland et al. report the results of a randomized, non-comparative phase 2 trial of neoadjuvant nivolumab or a combination of nivolumab and ipilimumab in patients with resectable retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma.

Christina L. Roland
Elise F. Nassif Haddad
Neeta Somaiah
Research13 Feb 2024
Nature Cancer

Volume: 5, P: 625-641
Angular Measurements of the Structure of 3C 446 and Other Quasars with High Red-shifts

G. K. MILEY
B. J. RICKETT
H. GENT
Research01 Dec 1967
Nature

Volume: 216, P: 974-976
A Theory of S Gene Structure

K. K. PANDEY
Research20 Oct 1962
Nature

Volume: 196, P: 236-238
Origin of Mammalian Trypanosomes which Develop in the Anterior-station of Blood-sucking Arthropods

P. T. K. WOO
Research12 Dec 1970
Nature

Volume: 228, P: 1059-1062
Comprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies

IFNγ signaling is important in the pathogenesis and immune response, emphasizing the need for investigation of its role. Here, the authors show that IFNγ plays a key role in shaping immune microenvironment in AML and developing resistance, providing insights for potential therapeutic strategies.

Bofei Wang
Patrick K. Reville
Hussein A. Abbas
ResearchOpen Access28 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Lithocholic acid facilitates release of angiocrine factors by liver sinusoidal endothelial cells during liver regeneration

Impreet Kaur
Aarti Sharma
Savneet Kaur
ResearchOpen Access30 Sept 2025
npj Gut and Liver

Volume: 2, P: 1-13
Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

Paralog synthetic lethals have been assessed with multiple CRISPR-based methods, but systematic comparison among these platforms is unavailable. Here, the authors systematically compare combinatorial perturbation platforms and establish the in4mer CRISPR/Cas12a multiplex knockout platform.

Nazanin Esmaeili Anvar
Chenchu Lin
Traver Hart
ResearchOpen Access27 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Dimensional reduction and incommensurate dynamic correlations in the \(S=\frac{1}{2}\) triangular-lattice antiferromagnet Ca₃ReO₅Cl₂

Frustration-induced dimensional reduction is manifested in lower dimensionality of magnetic correlations compared to that of the magnetic structure. Here the authors demonstrate the role of the uniform Dzyaloshinskii-Moriya interaction in the recently synthesized material Ca3ReO5Cl2 exhibiting dimensional reduction.

S. A. Zvyagin
A. N. Ponomaryov
K. Kindo
ResearchOpen Access23 Oct 2022
Nature Communications

Volume: 13, P: 1-6
Cryptosporidium PI(4)K inhibitor EDI048 is a gut-restricted parasiticidal agent to treat paediatric enteric cryptosporidiosis

EDI048 is a gastrointestinal-targeted Cryptosporidium PI(4)K inhibitor that undergoes a predictable metabolism and limits systemic exposure without compromising its anti-parasitic activity.

Ujjini H. Manjunatha
Suresh B. Lakshminarayana
Thierry T. Diagana
ResearchOpen Access08 Oct 2024
Nature Microbiology

Volume: 9, P: 2817-2835
Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

J.A. Roth
D. Nguyen
D. Cai
Research01 Sept 1996
Nature Medicine

Volume: 2, P: 985-991
Crystallization of Cytochrome b₂ Free of the Deoxyribonucleic Acid Component

R. K. MORTON
KATHRYN SHEPLEY
Research18 Nov 1961
Nature

Volume: 192, P: 639-641
Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium

C. F. Higgins
P. D. Haag
G. Ferro-Luzzi Ames
Research19 Aug 1982
Nature

Volume: 298, P: 723-727
Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results

In the final analysis of a phase 1 trial evaluating a lymph node-targeting mutant KRAS peptide vaccine combined with CpG in the adjuvant setting for patients with KRAS mutant pancreatic or colorectal cancer, median relapse-free survival and overall survival were not reached for patients with robust antigen-specific T cell responses, and these responses were durable with evidence of antigen spreading.

Zev A. Wainberg
Colin D. Weekes
Eileen M. O’Reilly
ResearchOpen Access11 Aug 2025
Nature Medicine

P: 1-6
Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response

Here the authors show that gain-of-function mutant p53s predispose cells to chromosomal instability by targeting MCMs, leading to activation of a cGAS-STING-non-canonical NF-κB signaling that promotes tumor metastasis and immunosuppression.

Mei Zhao
Tianxiao Wang
Ge Zhou
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-18
The Royal Botanic Garden, Calcutta

K. BISWAS
Research22 Jun 1940
Nature

Volume: 145, P: 959-962
Multiple scattering dynamics of fermions at an isolated p-wave resonance

Multiple scattering with wave-like atoms is known to produce non-trivial many-body effects. Here, the authors investigate multiple scattering in the semi-classical limit using deviations in the scattering halos produced by the collision of indistinguishable ultracold fermions.

R. Thomas
K. O. Roberts
N. Kjærgaard
ResearchOpen Access11 Jul 2016
Nature Communications

Volume: 7, P: 1-6
Biosynthetic Labelling of Mammalian Insulins in vitro

K. W. TAYLOR
D. G. PARRY
G. HOWARD SMITH
Research12 Sept 1964
Nature

Volume: 203, P: 1144-1145
Isolation of Infectious Ribonucleic Acid from Encephalomyocarditis and Mengo Encephalitis Viruses. The Effect of Sodium Deoxycholate

J. S. COLTER
RUTH A. CASPER
K. A. O. ELLEM
Research11 Aug 1962
Nature

Volume: 195, P: 585-586
DSDP Hole 504B, the first reference section over 1 km through Layer 2 of the oceanic crust

R. N. Anderson
J. Honnorez
R. L. Newmark
Research16 Dec 1982
Nature

Volume: 300, P: 589-594
Isolation from Spinach Chloroplasts of Particles Containing Different Proportions of Chlorophyll a and Chlorophyll b and their Possible Role in the Light Reactions of Photosynthesis

N. K. BOARDMAN
JAN M. ANDERSON
Research11 Jul 1964
Nature

Volume: 203, P: 166-167
Discrete Radio Sources at 38 Mc/s

O. B. SLEE
P. K. WRAITH
Research01 Jun 1967
Nature

Volume: 214, P: 971-974
Bowhead whale faeces link increasing algal toxins in the Arctic to ocean warming

An analysis of bowel samples from bowhead whales collected yearly from 2004–2022 indicates increasing algal toxin concentrations in Arctic food webs due to warming ocean conditions.

Kathi A. Lefebvre
Patrick Charapata
Rick Thoman
ResearchOpen Access09 Jul 2025
Nature

Volume: 644, P: 693-698
Conversion of Angiotensin I to Angiotensin II

K. K. F. NG
J. R. VANE
Research25 Nov 1967
Nature

Volume: 216, P: 762-766
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Molecular Species of the Urobilins

A. H. JACKSON
K. M. SMITH
D. C. NICHOLSON
Research05 Feb 1966
Nature

Volume: 209, P: 581-583
Spectroscopic Investigation of Rubredoxin and Ferredoxin

N. M. ATHERTON
K. GARBETT
J. E. STANGROOM
Research01 Nov 1966
Nature

Volume: 212, P: 590-593
Single-molecule quantum dot as a Kondo simulator

Tuning the structure in the atomic scale enables manipulation of the quantum state in a molecular based system. Here, Hiraokaet al. tune the Kondo coupling between molecular spins and the Au electrode by controlling the position of Fe²⁺ions in the molecular cage with a tip.

R. Hiraoka
E. Minamitani
N. Takagi
ResearchOpen Access30 Jun 2017
Nature Communications

Volume: 8, P: 1-7
Deformation of the Indo–Australian plate

Jeffrey K. Weissel
Roger N. Anderson
Carol A. Geller
Research01 Sept 1980
Nature

Volume: 287, P: 284-291
The source of dietary fat influences anti-tumour immunity in obese mice

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

Britta Kunkemoeller
Hannah Prendeville
Lydia Lynch
ResearchOpen Access25 Jul 2025
Nature Metabolism

Volume: 7, P: 1630-1645
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Clinical benefit or intestinal toxicity resulting from combined immune checkpoint blockade in patients with melanoma associates with prevalent commensal bacteria and can be decoupled by IL-1R inhibition.

Miles C. Andrews
Connie P. M. Duong
Jennifer A. Wargo
Research08 Jul 2021
Nature Medicine

Volume: 27, P: 1432-1441
Tomato bushy stunt virus at 5.5-Å resolution

F. K. Winkler
C. E. Schutt
G. Bricogne
Research10 Feb 1977
Nature

Volume: 265, P: 509-513
A humanized anaplastic lymphoma kinase (ALK)-directed antibody-drug conjugate with pyrrolobenzodiazepine payload demonstrates efficacy in ALK-expressing cancers

The native anaplastic lymphoma kinase (ALK) oncofetal protein is expressed in neuroblastoma and in multiple pediatric and adult solid tumors. Here, the authors show an ALK-directed antibody-drug conjugate with therapeutic efficacy in ALK-expressing preclinical models.

Alberto D. Guerra
Smita Matkar
Yael P. Mossé
ResearchOpen Access15 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L

The efficacy of antiangiogenic therapy in the clinic is often limited by the emergence of resistance. Here, the authors show that in ovarian cancer anti-VEGF inhibitors induce the overexpression of CD5L in endothelial cells through hypoxia-driven PPARy activation and that blocking CD5L can overcome resistance.

Christopher J. LaFargue
Paola Amero
Anil K. Sood
ResearchOpen Access26 Apr 2023
Nature Communications

Volume: 14, P: 1-18
Ground state selection under pressure in the quantum pyrochlore magnet Yb₂Ti₂O₇

An understanding of how quantum spin liquids arise in frustrated magnets at low temperatures remains elusive. Here the authors demonstrate a pressure-driven ferromagnetic transition out of a quantum spin liquid phase in the pyrochlore Yb₂Ti₂O₇, highlighting its proximity to a phase boundary.

E. Kermarrec
J. Gaudet
B. D. Gaulin
ResearchOpen Access15 Mar 2017
Nature Communications

Volume: 8, P: 1-5
Disorder-induced topological change of the superconducting gap structure in iron pnictides

The superconducting gap of most unconventional superconductors has nodes that support low-energy excitations. Mizukami et al. report that disorder introduced by electron irradiation in BaFe₂(As_1−xP_x)₂induces a sequence of transitions from a nodal to a nodeless gap and then to another gapless state.

Y. Mizukami
M. Konczykowski
T. Shibauchi
Research28 Nov 2014
Nature Communications

Volume: 5, P: 1-6
Peculiar variations in the structure of the quasar 3C454.3

I. I. K. Pauliny-Toth
R. W. Porcas
F. Mantovani
Research27 Aug 1987
Nature

Volume: 328, P: 778-782
ImmuneLENS characterizes systemic immune dysregulation in aging and cancer

Immune lymphocyte estimation from nucleotide sequencing (ImmuneLENS) infers B cell and T cell fractions from whole-genome sequencing data. Applied to the 100,000 Genomes Project datasets, circulating T cell fraction provides sex-dependent and prognostic insights in patients.

Robert Bentham
Thomas P. Jones
Nicholas McGranahan
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 694-705
A Genetically Determined Enzyme in the Pig

K.-B. AUGUSTINSSON
B. OLSSON
Research10 Sept 1960
Nature

Volume: 187, P: 924-925
Mannosyl D-Glucosamine Hydrochloride Isomers : Mannosyl D-Glucosamine Hydrochloride

S. A. BARKER
K. MURRAY
M. STACEY
Research08 Jul 1961
Nature

Volume: 191, P: 142-143
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Many tumors evade immunosurveillance by down-modulating expression of antigen-processing machinery and MHC molecules. Yang et al. report triple-negative tumor cell expression of the lncRNA LINK-A enhances degradation of antigen peptide-loading complex molecules and intrinsic tumor suppressors, which contribute to tumor persistence.

Qingsong Hu
Youqiong Ye
Liuqing Yang
Research03 Jun 2019
Nature Immunology

Volume: 20, P: 835-851
Free Oscillations of the Earth and the D″ Layer

K. J. MUIRHEAD
J. R. CLEARY
Research13 Sept 1969
Nature

Volume: 223, P: 1146
Global, regional and national burden of dietary iron deficiency from 1990 to 2021: a Global Burden of Disease study

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Sooji Lee
Yejun Son
Nicholas. J. Kassebaum
Research22 Apr 2025
Nature Medicine

Volume: 31, P: 1809-1829

Search

Filter By:

Search

Quick links