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Nature Immunology (2)
Mucosal Immunology (1)

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Structural basis for the killing of human beta cells by CD8⁺ T cells in type 1 diabetes

Much is known about crystal structures of MHC class II–autoreactive TCRs. Sewell and colleagues provide the structure of an MHC class I–autoreactive TCR and provide insight into the molecular basis of its diabetogenicity.

Anna M Bulek
David K Cole
Andrew K Sewell
Research15 Jan 2012
Nature Immunology

Volume: 13, P: 283-289
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

Psoriasis is associated with heightened T_H17 responses. Li and colleagues show that the IL-17R signaling adaptor Act1 requires the chaperone protein hsp90. Defective signaling leads to exuberant IL-22 production and enhanced disease.

Chenhui Wang
Ling Wu
Xiaoxia Li
Research02 Dec 2012
Nature Immunology

Volume: 14, P: 72-81
IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice

A Visperas
J S Do
B Min
Research16 Oct 2013
Mucosal Immunology

Volume: 7, P: 625-633