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Showing 1–4 of 4 results
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  • Carbon dioxide enrichment of a mature forest resulted in the emission of the excess carbon back into the atmosphere via enhanced ecosystem respiration, suggesting that mature forests may be limited in their capacity to mitigate climate change.

    • Mingkai Jiang
    • Belinda E. Medlyn
    • David S. Ellsworth
    Research
    Nature
    Volume: 580, P: 227-231
  • The development of a computational protein design method, meta-multistate design, enables the design and validation of protein variants termed DANCERs that spontaneously exchange between predicted conformational states on the millisecond timescale.

    • James A Davey
    • Adam M Damry
    • Roberto A Chica
    Research
    Nature Chemical Biology
    Volume: 13, P: 1280-1285
  • Damry et al. evaluates the impact of individual substitutions in primary sequence of a globular protein on its conformational dynamics. They demonstrate that only two mutations in core residues of a streptococcal protein (Gβ1) variant can synergistically create conformational exchange, one destabilizing the native structure while the other allowing two new conformational states to be accessed on the energy landscape.

    • Adam M. Damry
    • Marc M. Mayer
    • Roberto A. Chica
    ResearchOpen Access
    Communications Biology
    Volume: 2, P: 1-10