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Climate change is altering how plants balance carbon gain and water loss. This study maps global leaf-level water-use efficiency over the past two decades, showing it is highest in regions that are cold or dry, increasing worldwide, and strongly influenced by atmospheric dryness.

How the brain adapts its representations to prioritize task-relevant information remains unclear. Here, the authors show that both monkey brains and deep learning models stretch neural representations along goal-relevant dimensions, with spike timing playing a key role.

This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

The authors use femtosecond-timed Coulomb explosion to study in real time the bimolecular reaction of a single lithium ion diffusing toward a benzene dimer inside a liquid helium nanodroplet until formation of an ion-molecule complex.

Butterflies and moths are key indicators of functioning and healthy ecosystems around the world. This Review describes the evolutionary history of the order Lepidoptera and tracks shifts in researchers’ understanding of the clade in the genomic era; it also explores biogeographic patterns and conservation efforts for threatened species.

The ~500-metre-thick Prudhoe Dome in northwestern Greenland completely deglaciated 7,000 years ago, highlighting the sensitivity of the ice sheet to mid-Holocene warming, according to luminescence and geochemical data from sub-ice sediments and ice cores.

Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arrest and block phage dissemination.

The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of morphine, providing precise chronic pain relief without affecting sensory detection.

The enzyme PCMT1 was found to install a C-terminal cyclic imide modification on proteins that marks them for degradation by CRBN, uncovering a conserved protein turnover pathway with implications in metabolism and neurological function.

This study introduces a sediment-based method to reconstruct Antarctic fast-ice change during the late Holocene, revealing cyclic patterns linked to solar variability and offering insight into long-term cryosphere climate dynamics.

Here the authors explore dynamic connectivity associated with rumination in a large adolescent cohort, revealing that adult models do not generalize, while exploratory analyses suggest that variability in default-mode network connections may predict rumination, highlighting challenges in understanding depression risk factors.

Genes encoding key epigenetic regulators, including Lysine Demethylase 6A (KDM6A), are frequently mutated in bladder cancer. Here, the authors show that loss of KDM6A promotes formation of extrachromosomal circular DNA (eccDNA), genomic instability, and metabolic reprogramming, driving resistance to cisplatin chemotherapy while simultaneously enhancing sensitivity to immune checkpoint inhibitors.

A generative artificial intelligence-powered method enables de novo design of highly active enzymes based on information about the geometry of residues in the active site, without requiring protein backbone or sequence information.

Kathiriya et al. identify a cardiac progenitor lineage with expression of Tbx5 and anterior heart field-specific expression of Mef2c that bisects the intraventricular septum during development and show that alterations in this lineage lead to congenital heart defects in mice.

TDP-43 dysfunction in ALS/FTD causes faulty splicing of the KCNQ2 ion channel, leading to toxic protein buildup, neuron hyperactivity and a potential new biomarker and treatment target using RNA-based therapies.

Magneto-optical traps (MOTs) are a workhorse for laser cooling of atoms and were recently extended to molecules. Yet, new mechanisms for molecular trapping and cooling are still an open area of exploration. Here, the authors show a blue-detuned MOT based on a conveyor-belt effect for CaF molecules, yielding higher number densities, comparable with some atomic MOTs.

Off-target activation of nerve fibers is an ongoing problem in bioelectronic medicines such as vagus nerve stimulation. Here, the authors show that high-frequency stimulation can selectively block nerve fibers in the vagus nerve in swine models.

Aligning foundation models with human judgments enables them to more accurately approximate human behaviour and uncertainty across various levels of visual abstraction, while additionally improving their generalization performance.

The role of superconducting phase fluctuations in overdoped cuprates remains controversial. Here, the authors observe an unexpected nonmonotonic doping dependence of phase fluctuations in Bi_2+xSr_2−x−yLa_yCuO_6+δ, where vortex-like phase fluctuations are enhanced in both under- and overdoped samples.

In this study, the authors develop a flavivirus vaccine strategy by introducing mutations into envelope glycoproteins resulting in structural changes that conceal the ADE-prone fusion loop epitope. They show that the Zika virus-specific construct protects mice against viral challenge and prevents ADE by Dengue virus.

One-dimensional axial heterostructures were created by combining hydrogen-bonded organic frameworks (HOFs) and metal-organic frameworks (MOFs) through the control of different chemical bond characters. The MOF | HOF | MOF crystals showed interface-controlled gas diffusion and spatially-resolved fluorescence.

In a benchmark analysis comprising 5,609 clinical questions developed by 101 community health workers from Rwanda, a panel of 5 general large language models performed better than humans across all metrics.

Whether high-order frontal lobe areas receive raw speech input in parallel with early speech areas in the temporal lobe is unclear. Here, the authors show that frontal lobe areas get fast low-level speech information in parallel with temporal lobe speech areas.

Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layouts.

The highest-quality JWST spectra reveal that little red dots are young supermassive black holes shrouded in dense cocoons of ionized gas, where electron scattering, not Doppler motions, broadens their spectral lines.

This Article details the methods used for rigorous assessment of disease interventions in a multicenter preclinical trial. Using stroke models as proof of concept, it offers adaptable protocols for any field requiring robust preclinical validation.

A method of nanometre-level patterning of high-density extended 1D and 2D defects in thin films of perovskite oxides is developed.

After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.

Particle fusion is a promising process for constructing nanomaterials, but challenging to control in synthetic systems. Here, the authors report a method for kinetically regulated particle fusion controlled by variation in polymer chain length.

The quantum simulation of lattice gauge theories is anticipated to be an important scientific application of future quantum computing capabilities. This work elaborates on a formulation of lattice gauge theory quantum simulation that aims to require quantum computing techniques akin to those for simulating ϕ⁴ scalar field theory by utilizing non-compact continuous variable quantum degrees of freedom.

Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with gradient descent via backpropagation of error.

In social settings, people need to establish how much they contribute to shared outcomes. Here, the authors show that people strategically alter their actions to establish their level of control and identify neural activity underlying this process.

The research explores how ultrasound-based human-machine interfaces generalize across a wide variety of situations and participants. Robustness was achieved, with new users able to control virtual hands without the need for calibration.

Lightning Pose is an efficient pose estimation approach that requires few labeled training data owing to its semi-supervised learning strategy and ensembling.

DNA double-strand breaks endanger genome stability. Here, the authors present cryo-EM structures showing how Ku70/80 and DNA-PK bind DNA ends on nucleosomes, offering a mechanistic model for break recognition within chromatin.

Research in the tropics is unevenly distributed across regions and biomes. Here, the authors find that moist broadleaf forests account for 73% of all tropical citations but cover 29% of the land area, while drier, climate-vulnerable areas with fewer trees remain under-sampled and under-cited.

A transverse Peierls transition can occur when transverse acoustic phonons couple with conducting p-orbital electrons. Here, the authors observe an incommensurate transverse Peierls transition and signatures of a chiral charge density wave in EuAl₄.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Standard first line therapy in patients with non-small cell lung cancer is immunotherapy but responses vary and consistent predictive biomarkers are lacking. Here, using RNA-sequencing data from a large clinical trial in NSCLC patients, the authors define four molecular subsets with distinct tumour-intrinsic and -extrinsic features with differing outcomes to immunotherapy combinations.

The human superior temporal gyrus processes acoustic–phonetic properties of speech regardless of whether the language is familiar to the listener, but only encodes word boundaries and language-specific sound sequences if the language is known.

cSplotch compares spatial transcriptomics data across ages and regions of mouse colon tissue.

Antimatter remains an enigma – its absence in the universe is hitherto unexplained. Here, the authors report a breakthrough in the ability to study antihydrogen atoms to test fundamental symmetries. Antihydrogen atoms can now be accumulated at CERN at the previously unattainable rate of 2000 per hour.

This work presents a global wind power simulation tool that uses high-resolution data and extensive validation to improve accuracy. It corrects wind speed biases and validates against real-world data, enhancing reliability for wind energy assessments across various scales and regions.

This Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term in the context of therapeutic interventions.