In this study, the authors show that expression of Brn3a with Ngn1 or 2 can induce the direct reprogramming of mouse and human fibroblasts into peripheral sensory neurons. They further demonstrate that these neurons exhibit the expression profiles and physiological properties of mature sensory neurons and are responsive to nociceptor agonists.
- Joel W Blanchard
- Kevin T Eade
- Kristin K Baldwin
