N6-Methyladenosine (m6A) is a post-transcriptional RNA modification that modulates RNA structure through a destabilization of m6A base pairing. Here the authors use NMR and UV melting experiments and show that m6A can also stabilize m6A–U base pairs and global RNA structure when positioned adjacent to a 5ʹ bulge.
- Bei Liu
- Dawn K. Merriman
- Hashim M. Al-Hashimi
