Nature Search

A low-cost and shielding-free ultra-low-field brain MRI scanner

A low cost MRI scanner may have the potential to meet clinical needs at point of care or in low and middle income countries. Here the authors describe a low cost 0.055 Tesla MRI scanner that operates using a standard AC power outlet, and demonstrate its preliminary feasibility in diagnosing brain tumor and stroke.

Yilong Liu
Alex T. L. Leong
Ed X. Wu
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-14
An orally available M^pro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo

Authors present a bispecific antiviral design targeting the virus and the host that simultaneously offers broad-spectrum protection against multiple existing transmissible human-pathogenic coronaviruses, including the Paxlovid-resistant SARS-CoV-2 mutants.

Huiping Shuai
Jingxin Qiao
Hin Chu
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-24
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge

SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

Biao Zhou
Runhong Zhou
Zhiwei Chen
ResearchOpen Access23 Jun 2022
Nature Communications

Volume: 13, P: 1-14
Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong

Hong Kong experienced a severe wave of SARS-CoV-2 in early 2022. Here, the authors use genomic and serosurveillance data and show that this wave was dominated by the Omicron BA.2 sublineage, and that low protective immunity, particularly in older age groups, contributed to its severity.

Lin-Lei Chen
Syed Muhammad Umer Abdullah
Kelvin Kai-Wang To
ResearchOpen Access24 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

Hin Chu
Bingjie Hu
Kwok-Yung Yuen
ResearchOpen Access08 Jan 2021
Nature Communications

Volume: 12, P: 1-15
Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3

Here, the authors show that a single mutation in JN.1 spike, L455S, confers better spike cleavage and enhances virus infectivity in differentiated primary human nasal epithelial cells while increasing immune evasiveness, contributing to the efficient spread of JN.1.

Yuanchen Liu
Xiaoyu Zhao
Hin Chu
ResearchOpen Access09 Oct 2024
Nature Communications

Volume: 15, P: 1-17
Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

Drug used to treat Helicobacter pylori infection reduces SARS-CoV-2 viral loads in lungs and alleviates virus-associated pneumonia in a golden Syrian hamster model.

Shuofeng Yuan
Runming Wang
Hongzhe Sun
Research07 Oct 2020
Nature Microbiology

Volume: 5, P: 1439-1448
Coronaviruses exploit a host cysteine-aspartic protease for replication

Coronaviruses exploit the host caspase-6 to cleave coronavirus nucleocapsid protein into fragments with interferon-antagonizing activity to facilitate virus replication.

Hin Chu
Yuxin Hou
Kwok-Yung Yuen
Research03 Aug 2022
Nature

Volume: 609, P: 785-792
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Although extrapulmonary complications of different organ systems are recognized in patients with severe COVID19 effects are less well studied. Here, Qiao et al. characterize the pathogenesis of SARS-CoV-2 on bone metabolism in Syrian hamster and find that bone loss is associated with virus-mediated cytokine dysregulation.

Wei Qiao
Hui En Lau
Kelvin Wai-Kwok Yeung
ResearchOpen Access09 May 2022
Nature Communications

Volume: 13, P: 1-16
Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

Mitotic catastrophe is a regulated mechanism that responds to aberrant mitoses leading to removal of damaged cells. Here the authors reveal how replication stress induces mitotic death through pathways regulated by WAPL and telomere deprotection.

V. Pragathi Masamsetti
Ronnie Ren Jie Low
Anthony J. Cesare
ResearchOpen Access17 Sept 2019
Nature Communications

Volume: 10, P: 1-15
PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness

Glucose metabolism is crucial for cellular energy regulation and affects the immune response. Here the authors show that nutritional supplementation of mannose may be beneficial during virus infections by rewiring glucose metabolic dysregulation and alleviating inflammatory tissue damage.

Ronghui Liang
Zi-Wei Ye
Shuofeng Yuan
ResearchOpen Access08 Mar 2024
Nature Communications

Volume: 15, P: 1-15
Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

Until today effective antivirals for COVID-19 treatment are not widely available. Here, Zhao et al. characterize a dual-functional cross-linking peptide, 8P9R, that can inhibit SARS-CoV-2 virus entry in vitro and suppresses viral replication in vivo in golden Syrian hamster.

Hanjun Zhao
Kelvin K. W. To
Kwok-Yung Yuen
ResearchOpen Access09 Mar 2021
Nature Communications

Volume: 12, P: 1-9
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

Shuofeng Yuan
Xin Yin
Kwok-Yung Yuen
Research16 Mar 2021
Nature

Volume: 593, P: 418-423
Animal models in SARS-CoV-2 research

This Comment discusses the main animal models that have had a key role in our understanding of the immune and viral dynamics of SARS-CoV-2.

Hin Chu
Jasper Fuk-Woo Chan
Kwok-Yung Yuen
Comments & Opinion08 Apr 2022
Nature Methods

Volume: 19, P: 392-394
A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

Here Zhao et al. report a promising broad-spectrum antiviral alkaline peptide—P9R—that is active against several respiratory, pH-dependent viruses, including Influenza and SARS-CoV-2. P9R interferes with virus internalization by binding to the virus and subsequent inhibition of endosomal acidification.

Hanjun Zhao
Kelvin K. W. To
Kwok-Yung Yuen
ResearchOpen Access25 Aug 2020
Nature Communications

Volume: 11, P: 1-10
Infection of bat and human intestinal organoids by SARS-CoV-2

Bat and human intestinal organoids can support replication of SARS-CoV-2, enabling further characterization of the virus lifecycle and investigation of potential mechanisms of enteric infection in COVID-19.

Jie Zhou
Cun Li
Kwok Yung Yuen
Research13 May 2020
Nature Medicine

Volume: 26, P: 1077-1083
A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

Man Chun Chiu
Cun Li
Jie Zhou
ResearchOpen Access17 Jun 2022
Cell Discovery

Volume: 8, P: 1-15
Determination of seroprevalence and kinetics of humoral response using mpox virus A29 protein

Cai et al. develop and evaluate mpox A29 surface envelop protein-based enzyme immunoassay to analyze seroprevalence and B cell responses after natural mpox viral infection or vaccination. The assay can readily detect mpox A29-specific B cells and antibody in the serum of mpox patients and MVA-BN vaccine recipients.

Jian-Piao Cai
Wing-Ming Chu
Kelvin Kai-Wang To
ResearchOpen Access22 Nov 2023
Communications Medicine

Volume: 3, P: 1-9
COVID-19 drug discovery and treatment options

In this Review, Chan et al. explore major drug discovery approaches, preclinical antiviral evaluation models, virus-targeting and host-targeting therapeutic strategies, and key treatments currently used in clinical settings for COVID-19.

Jasper Fuk-Woo Chan
Shuofeng Yuan
Kwok-Yung Yuen
Reviews15 Apr 2024
Nature Reviews Microbiology

Volume: 22, P: 391-407
Humoral and cellular immunity against different SARS-CoV-2 variants in patients with chronic kidney disease

Desmond Yat-Hin Yap
Carol Ho-Yan Fong
Kelvin Kai-Wang To
ResearchOpen Access15 Nov 2023
Scientific Reports

Volume: 13, P: 1-12
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters

Hanjun Zhao
Kelvin Kai-Wang To
Kwok-Yung Yuen
ResearchOpen Access30 Jun 2022
Cell Discovery

Volume: 8, P: 1-15
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication

Shuofeng Yuan
Bingpeng Yan
Kwok-Yung Yuen
ResearchOpen Access26 Oct 2021
Cell Discovery

Volume: 7, P: 1-13
Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo

Hanjun Zhao
Chuyuan Zhang
Kwok-Yung Yuen
ResearchOpen Access03 Aug 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-10

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