The enzyme superoxide dismutase 1 (SOD1) protects cells from superoxide toxicity. Zychlinsky and colleagues find that post-translational glutathionylation of caspase-1 by SOD1 triggers caspase-1 activation and subsequent interleukin 1β production.
- Felix Meissner
- Kaaweh Molawi
- Arturo Zychlinsky